Protein TOPBP1 map

topoisomerase (DNA) II binding protein 1

 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / E2F1  map

PMID:17303408, PMID:16530042
TopBP1 contains 8 BRCT (BRCA1 carboxyl-terminal) motives.
PMID:12697828, PMID:15140942


c_re139( Cell cycle  map ):
Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.
PMID:15838517, PMID:12697828

In compartment: Nucleus
  1. TOPBP1@Nucleus map

In compartment: default

  1. TOPBP1@default map

Participates in complexes:
In compartment: Nucleus

  1. DP1*:​E2F1|​Lys_ace|​Ser31_pho:​TOPBP1@Nucleus map

In compartment: default

  1. ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map

Participates in reactions:
As Reactant or Product:

  1. DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + TOPBP1@Nucleus map map DP1*:​E2F1|​Lys_ace|​Ser31_pho:​TOPBP1@Nucleus map

  2. TOPBP1@default map + ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RAD17|​pho@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map

As Catalyser:

  1. CHEK1@default map map CHEK1|​pho|​active@default map

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