Protein TNPO1

Identifiers
transportin 1
“karyopherin (importin) beta 2″, KPNB2
HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1

Maps_Modules
 Survival   / WNT_NON_CANONICAL 

TNPO1@Cytoplasm

References
s_wnc2_re44( Survival  ):
Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT.
PMID:21278340
TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex
PMID:21709260

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Modifications:
In compartment: Cytoplasm

1. TNPO1@Cytoplasm

Participates in complexes:
In compartment: Cytoplasm

1. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm

2. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
3. CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
4. CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm

Participates in reactions:
As Reactant or Product:

1. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm → KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus

2. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus
3. Calmodulin*:​NFAT*:​PPP3R*@Cytoplasm + KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
4. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm + KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
5. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm + LRRK2@Cytoplasm + rNRON@Cytoplasm + CSE1L@Cytoplasm → CSE1L:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
6. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm + LRRK2@Cytoplasm + CSE1L@Cytoplasm + rNRON@Cytoplasm → CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm

As Catalyser: