TNFRSF1A

Protein TNFRSF1A map

Identifiers
tumor necrosis factor receptor superfamily, member 1A
HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 GENECARDS:TNFRSF1A REACTOME:66345 KEGG:7132 ATLASONC:GC_TNFRSF1A WIKI:TNFRSF1A
TNFR1

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

TNFRSF1A@Cytoplasm

References
a_re1278:( Apoptosis  map ) PMID:9915703

TNFRSF1A@Plasma Membrane

References
s_mpk1_re121( Survival  map ):
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. TNFRSF1A@Cytoplasm map

In compartment: Plasma Membrane

  1. TNFRSF1A@Plasma Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. BAG4:​TNFRSF1A@Cytoplasm map

In compartment: Plasma Membrane

  1. TNFRSF1A:​TRADD@Plasma Membrane map

  2. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  3. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

In compartment: TNFRSF1 Receptor Complex

  1. TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex map

Participates in reactions:
As Reactant or Product:

  1. TNF@Extracellular space map + TNFRSF1A@Cytoplasm map map TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex map

  2. TNFRSF1A@Cytoplasm map + BAG4@Cytoplasm map map BAG4:​TNFRSF1A@Cytoplasm map
  3. TNFRSF1A@Plasma Membrane map + TRADD@Cytoplasm map map TNFRSF1A:​TRADD@Plasma Membrane map
  4. TRAF2@Cytoplasm map + TNFRSF1A:​TRADD@Plasma Membrane map map TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  5. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  6. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  7. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  8. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1049
  9. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map
  10. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048

As Catalyser:

  1. TRADD@Cytoplasm map map TRADD@TNFRSF1 Receptor Complex map

  2. TRAF2@Cytoplasm map map TRAF2@TNFRSF1 Receptor Complex map
  3. DAB2IP@Cytoplasm map map DAB2IP@TNFRSF1 Receptor Complex map

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