Protein TNF

Identifiers
tumor necrosis factor
TNFA, “tumor necrosis factor (TNF superfamily, member 2)”
HUGO:TNF HGNC:11892 ENTREZ:7124 UNIPROT:P01375 GENECARDS:TNF REACTOME:66221 KEGG:7124 ATLASONC:TNFaID319 WIKI:TNF

Maps_Modules
 EMT   / EMT_REGULATORS 
 EMT   / ECM 
 Apoptosis   / TNF_RESPONSE 

References
PMID:19411070
TNFa dramatically enhanced the protein stabilization of Snail1 through NF-kB mediated CSN2 induction.

TNF@Extracellular space

References
e_re1218( EMT  ):
PMID:19411070
Activation of NFKB pathway by TNFa
TNFa dramatically enhanced the protein stabilization of Snail1 through NF-kB mediated CSN2 induction.

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Modifications:
In compartment: Extracellular space

1. TNF@Extracellular space

Participates in complexes:
In compartment: TNFRSF1 Receptor Complex

1. TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex

Participates in reactions:
As Reactant or Product:

1. TNF@Extracellular space + TNFRSF1A@Cytoplasm → TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex

2. TNF@Extracellular space → NF-_kappa_B_p65*@Cytoplasm

As Catalyser:

1. TRADD@Cytoplasm → TRADD@TNFRSF1 Receptor Complex

2. TRAF2@Cytoplasm → TRAF2@TNFRSF1 Receptor Complex
3. DAB2IP@Cytoplasm → DAB2IP@TNFRSF1 Receptor Complex