TLS_DNA_st1*

Gene TLS_DNA_st1* map

Identifiers
TLS:DNA:st1
DNA with AP site or ICL or intrastrand crosslinks. These lesions resulting in stalled replication fork, resolved by TLS during DNA replication.
Node_Type:Generic

Maps_Modules
 DNA repair  map  / TLS  map

References
PMID:22258607, PMID:22918414, PMID:21701511, PMID:23637285, PMID:23892398
UV double strand damage is repaired by TLS (ICL or intrastrand crosslinks)
PMID:22521143
For activation of TLS by cross-linking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263

gTLS_DNA_st1*@Nucleus

References
d_re516( DNA repair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For actovation of TLS by UV
PMID:22521143
For actIvation of TLS by interstrand crosslinking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263, PMID:21666254, PMID:20658647
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
d_re587:( DNA repair  map ) reactionType:is.a
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823


Modifications:
In compartment: Nucleus
  1. gTLS_DNA_st1*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

    2. gTLS_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    3. gIntact_DNA*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    4. gBER_B-glyc_DNA_st2*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    5. gBER_M-glyc_DNA_st2*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    6. gIntrastrand_crosslinks*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    7. gInterstrand_crosslinks_ICL*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    8. gBbulky_adducts*@Nucleus map map gTLS_DNA_st1*@Nucleus map
    9. Replication error@Nucleus map map gTLS_DNA_st1*@Nucleus map

    As Catalyser:

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