Gene TIMP2

Identifiers
TIMP metallopeptidase inhibitor 2
“tissue inhibitor of metalloproteinase 2″
HUGO:TIMP2 HGNC:11821 ENTREZ:7077 UNIPROT:P16035 GENECARDS:TIMP2 REACTOME:66055 KEGG:7077 ATLASONC:TIMP2ID42572ch17q25 WIKI:TIMP2

Maps_Modules
 EMT   / EMT_REGULATORS 
 EMT   / ECM 

gTIMP2@Nucleus

References
e_re1466( EMT  ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.

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Modifications:
In compartment: Nucleus

1. gTIMP2@Nucleus

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. gTIMP2@Nucleus → rTIMP2@Nucleus

As Catalyser: