Tight junctions

Phenotype Tight junctions map
Tight junctions@Extracellular space

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / DESMOSOMES  map

References
PMID:15151915
Tight cell juntions serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets.
Multicellular organisms are separated from the external environment by a layer of epithelial cells
The integrity of these epithelial cells is maintained by intercellular junctional complexes (tight junctions, adherens junctions, and desmosomes,
whereas gap junctions provide for intercellular communication.
e_re346( EMT  map ):
PMID:22949611
Signaling molecules act directly on polarity proteins, bypassing transcription factors such as Snail and Zeb1:
TGFBR1 binds to the tight junction protein Occludin and locally assembles into a complex containing Par6.
Activated TGFBR2 phosphorylates Par6, which binds to Smurf1 and causes RhoA ubiquitylation and the dissolution of junctions.
e_re653( EMT  map ):
GJB1 is so-called Connexin 32 or Cx32
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:17568974
Connexins induce and maintain tight junctions in epithelial cells.
e_re656( EMT  map ):
PMID:15292177
In mouse epithelial cells lacking any ZO-1 expression, there is retarded tight junction formation.
This phenotype was rescued by exogenous expression of ZO-1, but not by ZO-2, suggesting that these proteins are not functionally redundant
PMID:15980428

Tight junctions@Cytoplasm

References
s_wnc4_re33:( Survival  map ) PMID:18285450


Modifications:
In compartment: Cytoplasm
  1. Tight junctions@Cytoplasm map

In compartment: Extracellular space

  1. Tight junctions@Extracellular space map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. degraded map Tight junctions@Extracellular space map

    2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map map Tight junctions@Extracellular space map
    3. GTP:​RHOA@Cytoplasm map map Tight junctions@Extracellular space map
    4. JAM2:​JAM3@Extracellular space map map Tight junctions@Extracellular space map
    5. Occludin*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    6. Claudin1*:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
    7. Claudin2*:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
    8. Claudin1*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    9. Claudin2*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    10. Claudin3*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    11. Claudin1*:​Claudin3*@Cytoplasm map map Tight junctions@Extracellular space map
    12. Claudin2*:​Claudin3*@Cytoplasm map map Tight junctions@Extracellular space map
    13. Claudin3*:​Claudin5*@Cytoplasm map map Tight junctions@Extracellular space map
    14. Claudin5*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    15. Claudin14*|​hm2@Extracellular space map map Tight junctions@Extracellular space map
    16. Actin cytoskeletal*:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
    17. GJB1:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
    18. GJB1:​ZO1_2*@Cytoplasm map map Tight junctions@Extracellular space map
    19. GJA1:​ZO1*@Cytoplasm map map Tight junctions@Extracellular space map
    20. Tight junctions@Extracellular space map map Cell-cell adhesions@Extracellular space map
    21. EMT@Cytoplasm map map Tight junctions@Extracellular space map
    22. G_alpha__sub_12_endsub_*@Cytoplasm map map Tight junctions@Cytoplasm map

    As Catalyser:

      Leave a Reply