THBS1

Protein THBS1 map

Identifiers
thrombospondin 1
HUGO:THBS1 HGNC:11785 ENTREZ:7057 UNIPROT:P07996 GENECARDS:THBS1 REACTOME:66519 KEGG:7057 ATLASONC:THBS1ID42548ch15q15 WIKI:THBS1

Maps_Modules
 EMT  map  / ECM  map

References
PMID:8349738
THBS1 cleaves the latent TGFB1 complex, releasing TGFB in its active form
PMID:22943793

THBS1@Extracellular space

Maps_Modules
 EMT  map  / ECM  map

References
PMID:8349738
THBS1 cleaves the latent TGFB1 complex, releasing TGFB in its active form
PMID:22943793
e_re228( EMT  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP


Modifications:
In compartment: Extracellular space
  1. THBS1@Extracellular space map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map

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