E47 or TCF3 is upregulated in gastric cancer.
E47 or TCF3 or EA2 is upregulated in prostate cancer.
It could be an upstream regulator of Id1 and c-Myc which are highly expressed in prostate cancer.
It could acts as a tumor promoter at least in prostate cancer.
Snai1, Snai2, E47 transcription factors induce common and specific genetic programs, supporting a differential role of the factors in tumor progression and invasion.
e_re1225( EMT ):
Snai1 and TCF3 (E47) upregulate both mRNA and protein level of ID1
This upregulation depends on SP1 or AP1 co-transcription factors
Erk contributes to the recruitment or assembly of proteins to Id-1 promoter
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
e_re1239( EMT ):
Differential roles for Snail and E47 (both are E-cadherin repressors) in tumour progression:
Snail is implicated in promoting the initial invasion
E47 plays an active role in tumour cell growth by promoting angiogenesis.
In compartment: Nucleus
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- LEF1_TCF3_4*@Nucleus → TCF3@Nucleus
- TCF3@Nucleus → Angiogenesis@Nucleus
- E-protein*@Nucleus → TCF3@Nucleus
- rTCF3@Nucleus → TCF3@Nucleus