TCF3

Protein TCF3 map

Identifiers
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:17299729
E47 or TCF3 is upregulated in gastric cancer.
PMID:22564737
E47 or TCF3 or EA2 is upregulated in prostate cancer.
It could be an upstream regulator of Id1 and c-Myc which are highly expressed in prostate cancer.
It could acts as a tumor promoter at least in prostate cancer.
PMID:17018611
Snai1, Snai2, E47 transcription factors induce common and specific genetic programs, supporting a differential role of the factors in tumor progression and invasion.

TCF3@Nucleus

References
e_re1225( EMT  map ):
PMID:17490644
Snai1 and TCF3 (E47) upregulate both mRNA and protein level of ID1
This upregulation depends on SP1 or AP1 co-transcription factors
Erk contributes to the recruitment or assembly of proteins to Id-1 promoter
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
e_re1239( EMT  map ):
PMID:15169839
Differential roles for Snail and E47 (both are E-cadherin repressors) in tumour progression:
Snail is implicated in promoting the initial invasion
E47 plays an active role in tumour cell growth by promoting angiogenesis.


Modifications:
In compartment: Nucleus
  1. TCF3@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. LEF1_TCF3_4*@Nucleus map map TCF3@Nucleus map

    2. TCF3@Nucleus map map Angiogenesis@Nucleus map
    3. E-protein*@Nucleus map map TCF3@Nucleus map
    4. rTCF3@Nucleus map map TCF3@Nucleus map

    As Catalyser:

    1. gID1@Nucleus map map rID1@Nucleus map

    2. rID1@Nucleus map map ID1@Nucleus map
    3. gE-Cadherin*@Nucleus map map rE-Cadherin*@Nucleus map

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