TAK1*

Protein TAK1* map

Identifiers
mitogen-activated protein kinase kinase kinase 7
HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7
TAK1
MEKK7
MEKK7 TAK1

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
synonym:TAK1
TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways.
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6.
PMID:18855897 PMID:11274345

TAK1*|​T187_pho@TNFRSF1 Receptor Complex

References
a_re1339:( Apoptosis  map ) from uniprot
a_re334( Apoptosis  map ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2

TAK1*@TNFRSF1 Receptor Complex

References
a_re1340:( Apoptosis  map ) from uniprot


Modifications:
In compartment: Cytoplasm
  1. TAK1*@Cytoplasm map

In compartment: TNFRSF1 Receptor Complex

  1. TAK1*@TNFRSF1 Receptor Complex map

  2. TAK1*|​T187_pho@TNFRSF1 Receptor Complex map

Participates in complexes:
In compartment: Cytoplasm

  1. TAB1:​TAK1*@Cytoplasm map

  2. TAK1*|​pho:​TNFRSF1B@Cytoplasm map
  3. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  4. TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  5. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  6. TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm map
  7. ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  8. RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  9. IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map

In compartment: Nucleus

  1. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map

  2. NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. TAK1*@Cytoplasm map map TAK1*@TNFRSF1 Receptor Complex map

  2. TAK1*@TNFRSF1 Receptor Complex map map TAK1*|​T187_pho@TNFRSF1 Receptor Complex map
  3. TAK1*|​T187_pho@TNFRSF1 Receptor Complex map map TAK1*@TNFRSF1 Receptor Complex map
  4. TAK1*@Cytoplasm map + TAB*:​TGFBR1:​TGFBR2@Plasma Membrane map map TAB*:​TAK1*|​pho:​TGFBR1:​TGFBR2@Cytoplasm map
  5. TAK1*@Cytoplasm map + IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map map IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map
  6. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  7. TNFRSF1B:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map TAK1*|​pho:​TNFRSF1B@Cytoplasm map
  8. TAK1*@Cytoplasm map map TGF-_beta_ pathway@Nucleus map
  9. ROR2:​WNT1_3*@Cytoplasm map map TAB1:​TAK1*@Cytoplasm map
  10. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map + NLK|​T286_pho|​hm2|​active@Nucleus map + TAB2@Nucleus map map NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  11. TAK1*@Cytoplasm map + TAB1@Cytoplasm map map TAB1:​TAK1*@Cytoplasm map
  12. TAB1:​TAK1*@Cytoplasm map map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  13. TAK1*@Cytoplasm map map Immune system@Extracellular space map
  14. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  15. TGF-_beta_ pathway@Extracellular space map map TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  16. RCAN*|​T192_pho@Cytoplasm map + TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map map RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  17. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map map TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  18. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map + ROR2|​pho:​WNT3@Cytoplasm map map ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  19. ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map map WNT canonical pathway@Cytoplasm map

As Catalyser:

  1. CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex map map CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex map

  2. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm map
  3. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map
  4. MAP2K6@Cytoplasm map map MAP2K6|​pho|​pho@Cytoplasm map
  5. LEF_TCF*@Nucleus map map LEF_TCF*|​S166_pho|​T155_pho@Nucleus map
  6. TAB1:​TAK1*@Cytoplasm map map TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Cytoplasm map
  7. Calmodulin*:​KPNB1:​NFAT*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  8. ROR2:​WNT3@Cytoplasm map map ROR2|​pho:​WNT3@Cytoplasm map

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