survival PI3K_AKT_MTOR

Module: PI3K_AKT_mTOR map
This module consists of a cytosolic and nuclear part in which the signaling transduction pathway starting from a Receptor Tyrosine Kinase through activation of AKT and mTOR complexes. This will result in increased protein production and altered expression of the target genes.
======== References ========
PMID:7641885 Bossemeyer D (1995) Protein kinases–structure and function. FEBS Lett. 369(1);57-61.
PMID:9106657 LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E (1997) New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11(7);847-62.
PMID:9367342 Pagano M (1997) Cell cycle regulation by the ubiquitin pathway. FASEB J. 11(13);1067-75.
PMID:9735050 Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281(5381);1322-6.
PMID:9765224 Stennicke HR, J–rgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS (1998) Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 273(42);27084-90.
PMID:9779982 Porter AC, Vaillancourt RR (1998) Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene 17(11 Reviews);1343-52.
PMID:9812896 Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282(5392);1318-21.
PMID:9829964 Du K, Montminy M (1998) CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273(49);32377-9.
PMID:10026142 Kloeker S, Wadzinski BE (1999) Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. J. Biol. Chem. 274(9);5339-47.
PMID:10217147 Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398(6728);630-4.
PMID:10454566 Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF (1999) The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol. Cell. Biol. 19(9);6195-206.
PMID:10514377 Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286(5438);309-12.
PMID:10582334 Krystal G, Damen JE, Helgason CD, Huber M, Hughes MR, Kalesnikoff J, Lam V, Rosten P, Ware MD, Yew S, Humphries RK (1999) SHIPs ahoy. Int. J. Biochem. Cell Biol. 31(10);1007-10.
PMID:10611249 Chow CW, Davis RJ (1999) Integration of calcium and cyclic AMP signaling pathways by 14-3-3. Mol. Cell. Biol. 20(2);702-12.
PMID:10648629 Rodrigues GA, Falasca M, Zhang Z, Ong SH, Schlessinger J (2000) A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol. Cell. Biol. 20(4);1448-59.
PMID:10702316 Peterson RT, Beal PA, Comb MJ, Schreiber SL (2000) FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J. Biol. Chem. 275(10);7416-23.
PMID:10721693 Momand J, Wu HH, Dasgupta G (2000) MDM2–master regulator of the p53 tumor suppressor protein. Gene 242(1-2);15-29.
PMID:10722653 Toker A, Newton AC (2000) Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275(12);8271-4.
PMID:10722742 Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (2000) Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 275(12);8945-51.
PMID:10753867 Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE (2001) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275(15);10761-6.
PMID:10783894 Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404(6779);782-7.
PMID:10786854 Stutz F, Bachi A, Doerks T, Braun IC, S–raphin B, Wilm M, Bork P, Izaurralde E (2000) REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6(4);638-50.
PMID:10949026 Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell 6(1);41-51.
PMID:10995457 Sato S, Fujita N, Tsuruo T (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl. Acad. Sci. U.S.A. 97(20);10832-7.
PMID:11035045 Torres J, Pulido R (2000) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276(2);993-8.
PMID:11094066 Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW, Burgering BM, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (2000) Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol. Cell. Biol. 20(24);9138-48.
PMID:11108711 Martin KA, Schalm SS, Richardson C, Romanelli A, Keon KL, Blenis J (2000) Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. J. Biol. Chem. 276(11);7884-91.
PMID:11124803 Alt JR, Cleveland JL, Hannink M, Diehl JA (2000) Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev. 14(24);3102-14.
PMID:11154281 Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21(3);952-65.
PMID:11274345 Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81(2);807-69.
PMID:11278750 Cheung WM, Chu AH, Chu PW, Ip NY (2001) Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. J. Biol. Chem. 276(20);17083-91.
PMID:11313479 Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001) Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol. Cell. Biol. 21(10);3534-46.
PMID:11313945 Gual P, Giordano S, Anguissola S, Parker PJ, Comoglio PM (2001) Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling. Oncogene 20(2);156-66.
PMID:11463845 R–ssig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S (2001) Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol. Cell. Biol. 21(16);5644-57.
PMID:11500365 Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR (2001) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20(16);4380-90.
PMID:11516665 Harper JW (2001) Protein destruction: adapting roles for Cks proteins. Curr. Biol. 11(11);R431-5.
PMID:11532962 Le Hir H, Gatfield D, Izaurralde E, Moore MJ (2001) The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20(17);4987-97.
PMID:11554450 Sun Y, Tan M, Duan H, Swaroop M (2001) SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions. Antioxid. Redox Signal. 3(4);635-50.
PMID:11707428 Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR (2001) Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 276(52);48627-30.
PMID:11715018 Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC (2001) HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3(11);973-82.
PMID:11756412 Li Y, Dowbenko D, Lasky LA (2002) AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J. Biol. Chem. 277(13);11352-61.
PMID:11777939 Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G (2002) Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J. Cell Biol. 156(1);125-36.
PMID:11864996 Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB (2002) 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J. Cell Biol. 156(5);817-28.
PMID:11923280 Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y (2002) Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J. Biol. Chem. 277(24);21843-50.
PMID:11940581 Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277(26);23216-22.
PMID:11980723 Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR, Cohen P (2002) Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J. 21(9);2263-71.
PMID:11994454 Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 168(10);5024-31.
PMID:12040186 Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573);1655-7.
PMID:12107820 Baccarini M (2002) An old kinase on a new path: Raf and apoptosis. Cell Death Differ. 9(8);783-5.
PMID:12150925 Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110(2);163-75.
PMID:12391153 Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH (2002) Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol. Cell. Biol. 22(22);7842-52.
PMID:12408816 Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10(3);457-68.
PMID:12459251 Coqueret O (2002) Linking cyclins to transcriptional control. Gene 299(1-2);35-55.
PMID:12514131 Xu Z, Kukekov NV, Greene LA (2003) POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22(2);252-61.
PMID:12522211 Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (2003) Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J. Biol. Chem. 278(12);10041-7.
PMID:12529437 Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (2003) CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol. Biol. Cell 14(1);201-13.
PMID:12542976 Park MT, Lee SJ (2003) Cell cycle and cancer. J. Biochem. Mol. Biol. 36(1);60-5.
PMID:12615961 Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell. Sci. 116(Pt 7);1175-86.
PMID:12709531 Lasko P (2003) Gene regulation at the RNA layer: RNA binding proteins in intercellular signaling networks. Sci. STKE 2003(179);RE6.
PMID:12713446 Phin S, Kupferwasser D, Lam J, Lee-Fruman KK (2003) Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1. Biochem. J. 373(Pt 2);583-91.
PMID:12782630 Caloca MJ, Zugaza JL, Bustelo XR (2003) Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J. Biol. Chem. 278(35);33465-73.
PMID:12791379 Backers K, Blero D, Paternotte N, Zhang J, Erneux C (2003) The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases. Adv. Enzyme Regul. 43;15-28.
PMID:12792650 Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell Biol. 5(7);647-54.
PMID:12820959 Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW, Pavletich NP (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol. Cell 11(6);1445-56.
PMID:12844354 Mangus DA, Evans MC, Jacobson A (2003) Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol. 4(7);223.
PMID:12851486 Liang J, Slingerland JM (2003) Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2(4);339-45.
PMID:12867079 Pr–v–t D, Darlix JL, Ohlmann T (2003) Conducting the initiation of protein synthesis: the role of eIF4G. Biol. Cell 95(3-4);141-56.
PMID:14536078 Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM (2003) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol. Cell 12(2);381-92.
PMID:14551205 Astrinidis A, Senapedis W, Coleman TR, Henske EP (2003) Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J. Biol. Chem. 278(51);51372-9.
PMID:14585353 Luo J, Manning BD, Cantley LC (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4(4);257-62.
PMID:14664696 Zhao X, Gan L, Pan H, Kan D, Majeski M, Adam SA, Unterman TG (2003) Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem. J. 378(Pt 3);839-49.
PMID:15071497 Pintard L, Willems A, Peter M (2004) Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J. 23(8);1681-7.
PMID:15084260 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117(2);225-37.
PMID:15117942 Terui Y, Saad N, Jia S, McKeon F, Yuan J (2004) Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J. Biol. Chem. 279(27);28257-65.
PMID:15121840 Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A (2004) A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol. Cell. Biol. 24(10);4184-95.
PMID:15147722 M–r–y T, Geisen C (2004) Cyclin E. Int. J. Biochem. Cell Biol. 36(8);1424-39.
PMID:15160330 Kim R, Emi M, Tanabe K, Uchida Y, Toge T (2004) The role of Fas ligand and transforming growth factor beta in tumor progression: molecular mechanisms of immune privilege via Fas-mediated apoptosis and potential targets for cancer therapy. Cancer 100(11);2281-91.
PMID:15169778 Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, Hemmings BA (2004) Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J. Biol. Chem. 279(34);35510-7.
PMID:15187187 Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68(2);320-44.
PMID:15239952 Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E (2004) Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7(1);33-44.
PMID:15314020 Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev. 18(16);1926-45.
PMID:15337521 Johannessen M, Delghandi MP, Moens U (2004) What turns CREB on? Cell. Signal. 16(11);1211-27.
PMID:15340381 Cardozo T, Pagano M (2004) The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5(9);739-51.
PMID:15509806 Fern–ndez de Mattos S, Essafi A, Soeiro I, Pietersen AM, Birkenkamp KU, Edwards CS, Martino A, Nelson BH, Francis JM, Jones MC, Brosens JJ, Coffer PJ, Lam EW (2004) FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol. Cell. Biol. 24(22);10058-71.
PMID:15531880 Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, Yoshida M, Nakayama K, Nakayama KI (2004) Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat. Cell Biol. 6(12);1229-35.
PMID:15534002 Sasaki AT, Chun C, Takeda K, Firtel RA (2004) Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J. Cell Biol. 167(3);505-18.
PMID:15567848 Schlessinger J (2004) Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306(5701);1506-7.
PMID:15574420 Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P (2004) A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J. Biol. Chem. 280(7);5350-60.
PMID:15584861 Steelman LS, Bertrand FE, McCubrey JA (2004) The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. Expert Opin. Ther. Targets 8(6);537-50.
PMID:15668399 Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ (2005) Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl. Acad. Sci. U.S.A. 102(5);1649-54.
PMID:15688063 Petroski MD, Deshaies RJ (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6(1);9-20.
PMID:15755874 Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Mol. Cancer Res. 3(2);78-89.
PMID:15755954 Inoki K, Ouyang H, Li Y, Guan KL (2005) Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 69(1);79-100.
PMID:15766563 Hughes TA, Brady HJ (2005) E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem. Biophys. Res. Commun. 329(4);1267-74.
PMID:15808505 Gao T, Furnari F, Newton AC (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18(1);13-24.
PMID:15905173 Holz MK, Blenis J (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280(28);26089-93.
PMID:16039586 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC (2005) Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol. Cell 19(2);159-70.
PMID:16286006 Holz MK, Ballif BA, Gygi SP, Blenis J (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123(4);569-80.
PMID:16288286 Lian Z, Di Cristofano A (2005) Class reunion: PTEN joins the nuclear crew. Oncogene 24(50);7394-400.
PMID:16288288 Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24(50);7410-25.
PMID:16307918 Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A (2005) Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20(4);539-50.
PMID:16406523 Salomoni P, Khelifi AF (2006) Daxx: death or survival protein? Trends Cell Biol. 16(2);97-104.
PMID:16464865 Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL (2006) TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J. Biol. Chem. 281(13);8313-6.
PMID:16488589 Quatela SE, Philips MR (2006) Ras signaling on the Golgi. Curr. Opin. Cell Biol. 18(2);162-7.
PMID:16489074 Nakamura Y, Yasuoka H, Tsujimoto M, Yoshidome K, Nakahara M, Nakao K, Nakamura M, Kakudo K (2006) Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis. Clin. Cancer Res. 12(4);1201-7.
PMID:16511445 Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A (2006) A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441(7093);646-50.
PMID:16636147 Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL (2006) Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J. Cell Biol. 173(2);279-89.
PMID:16648474 Liu Q, Wilkins BJ, Lee YJ, Ichijo H, Molkentin JD (2006) Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol. Cell. Biol. 26(10);3785-97.
PMID:16679021 Ruvinsky I, Meyuhas O (2006) Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem. Sci. 31(6);342-8.
PMID:16680151 Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP (2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441(7092);523-7.
PMID:16697215 Lee MH, Lozano G (2006) Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Semin. Cancer Biol. 16(3);225-34.
PMID:16714285 Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H (2006) NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). J. Biol. Chem. 281(30);20749-60.
PMID:16847462 Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7(8);606-19.
PMID:16925947 Sun Y (2006) E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia 8(8);645-54.
PMID:16977332 Bao Q, Shi Y (2006) Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ. 14(1);56-65.
PMID:17052453 Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD (2006) S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol. Cell 24(2);185-97.
PMID:17053147 Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M (2006) S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314(5798);467-71.
PMID:17158541 Mitra AP, Datar RH, Cote RJ (2006) Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification. J. Clin. Oncol. 24(35);5552-64.
PMID:17218252 Baker SJ (2007) PTEN enters the nuclear age. Cell 128(1);25-8.
PMID:17218260 Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128(1);129-39.
PMID:17218261 Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128(1);141-56.
PMID:17218262 Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128(1);157-70.
PMID:17329932 Hwang GW (2007) Ubiquitin-proteasome system as a factor that determine the sensitivity to methylmercury. Yakugaku Zasshi 127(3);463-8.
PMID:17368478 Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD (2007) Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. J. Mol. Biol. 368(3);691-705.
PMID:17444818 Maccario H, Perera NM, Davidson L, Downes CP, Leslie NR (2007) PTEN is destabilized by phosphorylation on Thr366. Biochem. J. 405(3);439-44.
PMID:17461779 Pearce LR, Huang X, Boudeau J, Paw-?owski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 405(3);513-22.
PMID:17496910 McKay MM, Morrison DK (2007) Integrating signals from RTKs to ERK/MAPK. Oncogene 26(22);3113-21.
PMID:17565603 Siu YT, Jin DY (2007) CREB–a real culprit in oncogenesis. FEBS J. 274(13);3224-32.
PMID:17604271 Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (2007) PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 282(34);24514-24.
PMID:17613518 McKay MM, Morrison DK (2007) Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1. J. Biol. Chem. 282(36);26225-34.
PMID:17635922 Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M (2007) Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J. Biol. Chem. 282(37);27547-55.
PMID:17646672 Huang H, Tindall DJ (2007) Dynamic FoxO transcription factors. J. Cell. Sci. 120(Pt 15);2479-87.
PMID:17666529 Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ (2007) HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 104(32);13040-5.
PMID:17680028 Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res. 17(8);666-81.
PMID:17693255 Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130(3);440-55.
PMID:18000759 Ellenbroek SI, Collard JG (2007) Rho GTPases: functions and association with cancer. Clin. Exp. Metastasis 24(8);657-72.
PMID:18006823 Hattori T, Isobe T, Abe K, Kikuchi H, Kitagawa K, Oda T, Uchida C, Kitagawa M (2007) Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. Cancer Res. 67(22);10789-95.
PMID:18036779 Gan B, Guan JL (2007) FIP200, a key signaling node to coordinately regulate various cellular processes. Cell. Signal. 20(5);787-94.
PMID:18039929 Junttila MR, Li SP, Westermarck J (2007) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 22(4);954-65.
PMID:18042541 Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW (2007) Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J. Biol. Chem. 283(4);1882-92.
PMID:18077353 Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, Kuro-O M, Rothermel BA, Hill JA (2007) FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc. Natl. Acad. Sci. U.S.A. 104(51);20517-22.
PMID:18097445 Youle RJ, Strasser A (2007) The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9(1);47-59.
PMID:18199536 Yang H, Kong W, He L, Zhao JJ, O’Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ (2008) MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 68(2);425-33.
PMID:18249169 Tremblay ML, Gigu–re V (2008) Phosphatases at the heart of FoxO metabolic control. Cell Metab. 7(2);101-3.
PMID:18291711 Rosner M, Hanneder M, Siegel N, Valli A, Hengstschl–ger M (2008) The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. Mutat. Res. 658(3);234-46.
PMID:18298802 Zheng L, Ding H, Lu Z, Li Y, Pan Y, Ning T, Ke Y (2008) E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6. Genes Cells 13(3);285-94.
PMID:18308511 Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V (2008) Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell. Signal. 20(6);1084-91.
PMID:18372248 Wang L, Harris TE, Lawrence JC (2008) Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J. Biol. Chem. 283(23);15619-27.
PMID:18381890 Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y (2008) WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 22(7);866-71.
PMID:18391071 Culjkovic B, Tan K, Orolicki S, Amri A, Meloche S, Borden KL (2008) The eIF4E RNA regulon promotes the Akt signaling pathway. J. Cell Biol. 181(1);51-63.
PMID:18414028 Blain SW (2008) Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle 7(7);892-8.
PMID:18423201 Ma XM, Yoon SO, Richardson CJ, J–lich K, Blenis J (2008) SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133(2);303-13.
PMID:18466115 Huang J, Manning BD (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem. J. 412(2);179-90.
PMID:18481918 Obsilov– V, Silhan J, Boura E, Teisinger J, Obsil T (2008) 14-3-3 proteins: a family of versatile molecular regulators. Physiol Res 57 Suppl 3;S11-21.
PMID:18511290 Brognard J, Newton AC (2008) PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 19(6);223-30.
PMID:18559511 Krauss S, Foerster J, Schneider R, Schweiger S (2008) Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 68(12);4658-65.
PMID:18562292 Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D (2008) The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc. Natl. Acad. Sci. U.S.A. 105(25);8585-90.
PMID:18566586 Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 27(14);1932-43.
PMID:18570873 Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM (2008) mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol. Cell 30(6);701-11.
PMID:18588945 Eichhorn PJ, Creyghton MP, Bernards R (2008) Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta 1795(1);1-15.
PMID:18636226 Vervoorts J, L–scher B (2008) Post-translational regulation of the tumor suppressor p27(KIP1). Cell. Mol. Life Sci. 65(20);3255-64.
PMID:18644865 Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, Wymann MP, Brosens JJ, Schulze A, Lam EW (2008) The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol. Cell. Biol. 28(19);5886-98.
PMID:18716620 Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP (2008) The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455(7214);813-7.
PMID:18787170 Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321(5895);1499-502.
PMID:18802401 Bayascas JR (2008) Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways. Cell Cycle 7(19);2978-82.
PMID:18851840 Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M (2008) Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol. Cell 32(1);140-9.
PMID:18925875 Garc–a-Mart–nez JM, Alessi DR (2008) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416(3);375-85.
PMID:19027299 Morrison DK (2008) The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol. 19(1);16-23.
PMID:19143635 Huang J, Manning BD (2009) A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37(Pt 1);217-22.
PMID:19151919 Bosco EE, Mulloy JC, Zheng Y (2009) Rac1 GTPase: a "Rac" of all trades. Cell. Mol. Life Sci. 66(3);370-4.
PMID:19216069 Ito K, Bernardi R, Pandolfi PP (2009) A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr. Opin. Genet. Dev. 19(1);51-9.
PMID:19218564 Nayak A, Gl–ckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F (2009) Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. J. Biol. Chem. 284(16);10935-46.
PMID:19225151 Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20(7);1992-2003.
PMID:19244117 Copp J, Manning G, Hunter T (2009) TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 69(5);1821-7.
PMID:19321440 Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W (2009) MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J. Biol. Chem. 284(21);13987-4000.
PMID:19339977 Ma XM, Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10(5);307-18.
PMID:19352404 Schulman BA, Harper JW (2009) Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat. Rev. Mol. Cell Biol. 10(5);319-31.
PMID:19356152 Lankat-Buttgereit B, G–ke R (2009) The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol. Cell 101(6);309-17.
PMID:19387550 Miyata Y (2009) Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. Cell. Mol. Life Sci. 66(11-12);1840-9.
PMID:19440234 Abbas T, Dutta A (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer 9(6);400-14.
PMID:19446321 Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137(5);873-86.
PMID:19459846 Kitagawa K, Kotake Y, Kitagawa M (2009) Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100(8);1374-81.
PMID:19556239 Zhang W, Yang J, Liu Y, Chen X, Yu T, Jia J, Liu C (2009) PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation. J. Biol. Chem. 284(34);22649-56.
PMID:19568798 Gunn RM, Hailes HC (2009) Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol 1(1-4);49-62.
PMID:19574223 Guttilla IK, White BA (2009) Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J. Biol. Chem. 284(35);23204-16.
PMID:19584721 Lang F, Artunc F, Vallon V (2009) The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr. Opin. Nephrol. Hypertens. 18(5);439-48.
PMID:19597330 Fischer PM (2009) Cap in hand: targeting eIF4E. Cell Cycle 8(16);2535-41.
PMID:19597351 Yim EK, Siwko S, Lin SY (2009) Exploring Rak tyrosine kinase function in breast cancer. Cell Cycle 8(15);2360-4.
PMID:19615955 Fehrenbacher N, Bar-Sagi D, Philips M (2009) Ras/MAPK signaling from endomembranes. Mol Oncol 3(4);297-307.
PMID:19641503 Lomonosova E, Chinnadurai G (2009) BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27 Suppl 1;S2-19.
PMID:19652529 Brauer PM, Tyner AL (2009) RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle 8(17);2728-32.
PMID:19652530 Chipuk JE, Green DR (2009) PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle 8(17);2692-6.
PMID:19662498 Di Maira G, Brustolon F, Pinna LA, Ruzzene M (2009) Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells. Cell. Mol. Life Sci. 66(20);3363-73.
PMID:19685005 Park J, Song WJ, Chung KC (2009) Function and regulation of Dyrk1A: towards understanding Down syndrome. Cell. Mol. Life Sci. 66(20);3235-40.
PMID:19706736 Proud CG (2010) Dynamic balancing: DEPTOR tips the scales. J Mol Cell Biol 1(2);61-3.
PMID:19720745 Dibble CC, Asara JM, Manning BD (2009) Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol. Cell. Biol. 29(21);5657-70.
PMID:19788417 Allan LA, Clarke PR (2009) Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. FEBS J. 276(21);6063-73.
PMID:19797085 Li X, Liu J, Gao T (2009) beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol. Cell. Biol. 29(23);6192-205.
PMID:19864431 Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J. Biol. Chem. 285(1);80-94.
PMID:19887899 Lee J, Kim SS (2010) The function of p27 KIP1 during tumor development. Exp. Mol. Med. 41(11);765-71.
PMID:19893571 Wertz IE, Dixit VM (2010) Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ. 17(1);14-24.
PMID:19934277 Akiyama T, Dass CR, Choong PF (2010) Bim-targeted cancer therapy: a link between drug action and underlying molecular changes. Mol. Cancer Ther. 8(12);3173-80.
PMID:19941614 Stipanuk MH (2010) Macroautophagy and its role in nutrient homeostasis. Nutr. Rev. 67(12);677-89.
PMID:20025601 Yang Z, Song L, Huang C (2010) Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades. Curr Cancer Drug Targets 9(8);915-30.
PMID:20027184 Pearce LR, Komander D, Alessi DR (2010) The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11(1);9-22.
PMID:20056399 Mizushima N (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 22(2);132-9.
PMID:20068088 Degenhardt Y, Lampkin T (2010) Targeting Polo-like kinase in cancer therapy. Clin. Cancer Res. 16(2);384-9.
PMID:20083225 van Jaarsveld MT, Helleman J, Berns EM, Wiemer EA (2010) MicroRNAs in ovarian cancer biology and therapy resistance. Int. J. Biochem. Cell Biol. 42(8);1282-90.
PMID:20138985 Nascimento EB, Snel M, Guigas B, van der Zon GC, Kriek J, Maassen JA, Jazet IM, Diamant M, Ouwens DM (2010) Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cell. Signal. 22(6);961-7.
PMID:20146692 Orlova KA, Crino PB (2010) The tuberous sclerosis complex. Ann. N. Y. Acad. Sci. 1184;87-105.
PMID:20214616 Carnero A (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des. 16(1);34-44.
PMID:20300203 Isra–l A (2010) The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2(3);a000158.
PMID:20338997 Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D (2010) mTOR complex-2 activates ENaC by phosphorylating SGK1. J. Am. Soc. Nephrol. 21(5);811-8.
PMID:20398329 Wickenden JA, Watson CJ (2010) Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. Breast Cancer Res. 12(2);202.
PMID:20452955 Lallemand-Breitenbach V, de Th– H (2010) PML nuclear bodies. Cold Spring Harb Perspect Biol 2(5);a000661.
PMID:20506250 Gong X, Ming X, Deng P, Jiang Y (2010) Mechanisms regulating the nuclear translocation of p38 MAP kinase. J. Cell. Biochem. 110(6);1420-9.
PMID:20537194 Mishra R (2010) Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol. Cancer 9;144.
PMID:20540941 Thomas LW, Lam C, Edwards SW (2010) Mcl-1; the molecular regulation of protein function. FEBS Lett. 584(14);2981-9.
PMID:20580290 Blyth K, Vaillant F, Jenkins A, McDonald L, Pringle MA, Huser C, Stein T, Neil J, Cameron ER (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells Mol. Dis. 45(2);117-23.
PMID:20647036 Saletta F, Suryo Rahmanto Y, Richardson DR (2011) The translational regulator eIF3a: the tricky eIF3 subunit! Biochim. Biophys. Acta 1806(2);275-86.
PMID:20673124 van der Vos KE, Coffer PJ (2011) The extending network of FOXO transcriptional target genes. Antioxid. Redox Signal. 14(4);579-92.
PMID:20679392 Manfredi JJ (2010) The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev. 24(15);1580-9.
PMID:20709625 Ghibelli L, Diederich M (2011) Multistep and multitask Bax activation. Mitochondrion 10(6);604-13.
PMID:20832730 Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W (2010) Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol. Cell 39(5);797-808.
PMID:20932932 Fenton TR, Gout IT (2011) Functions and regulation of the 70kDa ribosomal S6 kinases. Int. J. Biochem. Cell Biol. 43(1);47-59.
PMID:20935674 Pavet V, Portal MM, Moulin JC, Herbrecht R, Gronemeyer H (2011) Towards novel paradigms for cancer therapy. Oncogene 30(1);1-20.
PMID:20946121 Onodera Y, Miki Y, Suzuki T, Takagi K, Akahira J, Sakyu T, Watanabe M, Inoue S, Ishida T, Ohuchi N, Sasano H (2010) Runx2 in human breast carcinoma: its potential roles in cancer progression. Cancer Sci. 101(12);2670-5.
PMID:21102635 Vigil D, Cherfils J, Rossman KL, Der CJ (2011) Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10(12);842-57.
PMID:21157483 Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12(1);21-35.
PMID:21177869 Liu J, Stevens PD, Gao T (2011) mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. J. Biol. Chem. 286(8);6510-20.
PMID:21179058 Youle RJ, Narendra DP (2011) Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12(1);9-14.
PMID:21233202 Hutchinson JA, Shanware NP, Chang H, Tibbetts RS (2011) Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J. Biol. Chem. 286(10);8688-96.
PMID:21386996 Kveiborg M, Instrell R, Rowlands C, Howell M, Parker PJ (2011) PKC– and PKC– regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS ONE 6(2);e17168.
PMID:21474067 Saci A, Cantley LC, Carpenter CL (2011) Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol. Cell 42(1);50-61.
PMID:21505104 Zhang H, Pan Y, Zheng L, Choe C, Lindgren B, Jensen ED, Westendorf JJ, Cheng L, Huang H (2011) FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion. Cancer Res. 71(9);3257-67.
PMID:21751375 Xia Z, Guo M, Ma H (2011) Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays. Proteomics 11(17);3444-51.
PMID:22290435 Curtis CD, Griffin CT (2012) The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol. Cell. Biol. 32(7);1312-20.
PMID:22699938 Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y, Fang W, Zhu WG, Zhang H (2012) Kindlin 2 forms a transcriptional complex with —catenin and TCF4 to enhance Wnt signalling. EMBO Rep. 13(8);750-8.
PMID:22761862 Yang T, Cai SY, Zhang J, Lu JH, Lin C, Zhai J, Wu MC, Shen F (2013) Kr–ppel-like factor 8 is a new Wnt/beta-catenin signaling target gene and regulator in hepatocellular carcinoma. PLoS ONE 7(6);e39668.
PMID:23308069 Perchiniak EM, Groden J (2011) Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC. Curr Colorectal Cancer Rep 7(2);145-151.
======== References ========

Leave a Reply