soc-2 suppressor of clear homolog (C. elegans)
“soc-2 (suppressor of clear C.elegans) homolog”
HUGO:SHOC2 HGNC:15454 ENTREZ:8036 UNIPROT:Q9UQ13 GENECARDS:SHOC2 KEGG:8036 ATLASONC:GC_SHOC2 WIKI:SHOC2
Sur-8 contributes to the Raf activation process by promoting the dephosphorylation of the inhibitory N-terminal 14-3-3 binding site on Raf.
s_mpk1_re13( Survival ):
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high aﬃnity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910
s_mpk1_re21( Survival ):
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway.
s_mpk1_re55( Survival ):
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf and thus its recruitment.
s_mpk1_re62( Survival ):
The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles.
The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation.
s_s_mpk1_re21( Survival ):
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + BRAF@Cytoplasm → BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
- RAF1@Cytoplasm + GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes → GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes
- RAF1@Cytoplasm + Ca2+:DAG:RAS*|pho:RASGRP1@Golgi Apparatus → Ca2+:DAG:RAF1|pho:RAS*|pho:RASGRP1@Golgi Apparatus
- GPCR*|pho:GRK*:_beta_-Arrestin2*@Plasma Membrane + ERK*@Cytoplasm + RAF1@Cytoplasm + MEK*@Cytoplasm → ERK*|pho|pho:GPCR*:GRK*:MEK*|pho|pho:RAF1|pho:_beta_-Arrestin2*@Early Endosomes