SUR-8*

Protein SUR-8* map

Identifiers
soc-2 suppressor of clear homolog (C. elegans)
“soc-2 (suppressor of clear C.elegans) homolog”
HUGO:SHOC2 HGNC:15454 ENTREZ:8036 UNIPROT:Q9UQ13 GENECARDS:SHOC2 KEGG:8036 ATLASONC:GC_SHOC2 WIKI:SHOC2

Maps_Modules
 Survival  map  / MAPK  map

References
Sur-8 contributes to the Raf activation process by promoting the dephosphorylation of the inhibitory N-terminal 14-3-3 binding site on Raf.
PMID:17496910

SUR-8*@Cytoplasm

References
s_mpk1_re13( Survival  map ):
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high affinity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910
s_mpk1_re21( Survival  map ):
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK map signalling pathway.
PMID:19289794 PMID:17496910
s_mpk1_re55( Survival  map ):
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf and thus its recruitment.
PMID:17496910
s_mpk1_re62( Survival  map ):
The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles.
The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation.
PMID:11226259 PMID:19565474
s_s_mpk1_re21( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. SUR-8*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + BRAF@Cytoplasm map map BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

      2. RAF1@Cytoplasm map + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
      3. RAF1@Cytoplasm map + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map map Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
      4. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map + ERK*@Cytoplasm map + RAF1@Cytoplasm map + MEK*@Cytoplasm map map ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map

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