STK11

Protein STK11 map

Identifiers
serine/threonine kinase 11
HUGO:STK11 HGNC:11389 ENTREZ:6794 UNIPROT:Q15831 GENECARDS:STK11 REACTOME:65200 KEGG:6794 ATLASONC:STK11ID292 WIKI:STK11

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map

References
synonym:LKB1

STK11|​K48_ace|​T366_unk@Nucleus

References
a_re468:( Apoptosis  map ) PMID:18687677

STK11|​T366_unk@Nucleus

References
a_re469:( Apoptosis  map ) PMID:18687677
a_re1047:( Apoptosis  map ) reactionType:is.a

STK11|​K48_unk|​T366_pho@Nucleus

References
a_re1046( Apoptosis  map ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
a_re1048:( Apoptosis  map ) reactionType:is.a

STK11|​K48_unk@Nucleus

References
a_re1046( Apoptosis  map ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
a_re1516:( Apoptosis  map ) reactionType:is.a

STK11|​K48_unk|​T366_unk|​active@Nucleus

References
a_re1047:( Apoptosis  map ) reactionType:is.a
a_re467:( Apoptosis  map ) PMID:18687677

STK11@Nucleus

References
a_re1516:( Apoptosis  map ) reactionType:is.a


Modifications:
In compartment: Nucleus
  1. STK11@Nucleus map

  2. STK11|​K48_unk@Nucleus map
  3. STK11|​T366_unk@Nucleus map
  4. STK11|​K48_ace|​T366_unk@Nucleus map
  5. STK11|​K48_unk|​T366_pho@Nucleus map
  6. STK11|​K48_unk|​T366_unk|​active@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. CAB39:​STK11|​K48_unk|​T366_unk|​active:​STRADA@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. DDIT4|​pho|​ubi@Cytoplasm map map CAB39:​STK11|​K48_unk|​T366_unk|​active:​STRADA@Cytoplasm map

  2. STK11|​K48_unk@Nucleus map map STK11|​K48_unk|​T366_pho@Nucleus map
  3. STK11|​T366_unk@Nucleus map map STK11|​K48_unk|​T366_unk|​active@Nucleus map
  4. STK11|​K48_unk|​T366_pho@Nucleus map map STK11|​K48_unk|​T366_unk|​active@Nucleus map
  5. STK11|​K48_unk@Nucleus map map STK11@Nucleus map
  6. STK11|​T366_unk@Nucleus map map STK11@Nucleus map
  7. STK11|​K48_unk|​T366_unk|​active@Nucleus map + STRADA@Nucleus map + CAB39@Cytoplasm map map CAB39:​STK11|​K48_unk|​T366_unk|​active:​STRADA@Cytoplasm map
  8. STK11|​T366_unk@Nucleus map map STK11|​K48_ace|​T366_unk@Nucleus map
  9. STK11|​K48_ace|​T366_unk@Nucleus map map STK11|​T366_unk@Nucleus map

As Catalyser:

  1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm map

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