Src family kinases*

Protein Src family kinases* map

Identifiers
Src family kinases*
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC
c-src tyrosine kinase
HUGO:CSK HGNC:2444 ENTREZ:1445 UNIPROT:P41240 GENECARDS:CSK REACTOME:52852 ATLASONC:GC_CSK WIKI:CSK
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241 GENECARDS:FYN REACTOME:55160 KEGG:2534 ATLASONC:GC_FYN WIKI:FYN

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:16492141
Binding partners proteins of Connexin 43 (GJA1):
-Kinases: v-Src, c-Src, PKC, PKA, MAPK, Casein kinase 1, Cdc2 kinase
-TIGHT_JUNCTIONS scaffold proteins: ZO1, ZO2, caveolin 1
-Cytoskeleton: b-catenin, a-tubulin, b-tubulin
-Others: Drebrin, NOV, CIP85
PMID:9278444
Reduction of gap junctional communication in v-src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein, connexin 43
SH3 and SH2 domains of v-Src bind to proline-rich motifs and a phosphorylated tyrosine residue in the C-terminal tail of Cx43
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation


Modifications:
In compartment: Cytoplasm
  1. Src family kinases*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Src family kinases*@Cytoplasm map map v-SRC*@Cytoplasm map

    2. Src family kinases*@Cytoplasm map map c-SRC*|​Y_pho|​active@Cytoplasm map
    3. Src family kinases*@Cytoplasm map map FYN@Cytoplasm map
    4. Src family kinases*@Cytoplasm map map FAK1*|​emp@Cytoplasm map
    5. Src family kinases*@Cytoplasm map map PTK2B@Cytoplasm map
    6. Src family kinases*@Cytoplasm map map ABL1@Cytoplasm map

    As Catalyser:

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