SOX2

Protein SOX2 map

Identifiers
SRY (sex determining region Y)-box 2
HUGO:SOX2 HGNC:11195 ENTREZ:6657 UNIPROT:P48431 GENECARDS:SOX2 KEGG:6657 ATLASONC:SOX2ID44064ch3q26 WIKI:SOX2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

SOX2@Nucleus

References
e_re1200( EMT  map ):
PMID:19935649
Expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.
ZEB1 knockdown not only resulted in reduced invasion and metastasis, but also in reduced tumorigenicity.
ZEB1 is also necessary for the self-renewing capacity.
ZEB1 is crucial for drug resistance in pancreatic cancer cells. This supports data showing that EMT activators (Twist and Snail) confer anti-apoptotic properties


Modifications:
In compartment: Nucleus
  1. SOX2@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. rSOX2@Nucleus map map SOX2@Nucleus map

    As Catalyser:

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