SNAI2

Protein SNAI2 map

Identifiers
snail homolog 2
HUGO:SNAI2 HGNC:11094 ENTREZ:6591 UNIPROT:O43623 GENECARDS:SNAI2 KEGG:6591 ATLASONC:SNAI2ID453 WIKI:SNAI2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:22370643

SNAI2@Nucleus

References
e_re9( EMT  map ):
PMID:19448627
Wild-type p53 inhibits Slug protein expression.
Slug protein levels were significantly decreased in parallel with increased wtp53 accumulation.
Slug mRNA levels did not change indicating that Slug is not transcriptionally regulated by wtp53
e_re2( EMT  map ):
PMID:20731704
PMID:21317430
In NMuMG cells treated with TGFB1 Snail1 RNA and protein are induced 1 h after addition of the cytokine preceding Zeb1 up-regulation that requires 6–8 h.
Zeb1 gene expression is caused by increased RNA levels but also by enhanced protein stability and is markedly dependent on Snail1 because depletion of this protein prevents Zeb1 protein and RNA up-regulation
PMID:22406545
TGFB can activate both SNAI1 and SNAI2 and thus promote EMT via both SMAD-dependent and -independent pathways
PMID:14623871
Activation of Slug (SNAI2) by two mechanisms:
-transcriptional activation of Slug by the CTNNB1and TCF/LEF complex
-activation of the ERK pathway.
When adherens junctions are established in dense cultures, ErbB1/2 and the ERK pathway become inactive, CTNNB1 is localized at adherens junctions, Slug expression is reduced, and E-cadherin transcription is induced.
Antibody-mediated disruption of adherens junctions led to nuclear CTNNB1 localization and enhanced beta-catenin signaling, induction of Slug and inhibition of E-cadherin expression.
PMID:17093497
PMID:12490555
Snail1 induces Snail2 transcription.
Snail is able to induce the expression of Slug and all other neural crest markers (Zic5, FoxD3, Twist and Ets1)
PMID:16510505
Snail2 activates the Snail2 promoter
PMID:21199805
Twist1 binds to an E-box on the proximate Snail2 promoter to induce its transcription.
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
PMID:17550342
Activation of KIT by binding to KITLG induces SNAI2 expression
e_re26( EMT  map ):
PMID:21051859
TCF3 (E47) is upregulated by Snail1, Snail2, Zeb1.
e_re523( EMT  map ):
PMID:12668723
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
PMID:16232121
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
PMID:15151915
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression
e_re1216( EMT  map ):
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
Complex of p53, MDM2 and Slug faciliates the proteasomal degradation of Slug by MDM2.


Modifications:
In compartment: Nucleus
  1. SNAI2@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map

  2. CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. SNAI2@Nucleus map + MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map

  2. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map map degraded
  3. SNAI2@Nucleus map + CTBP1_2*@Nucleus map + HDAC1@Nucleus map + HDAC3@Nucleus map map CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus map
  4. rSNAI2@Nucleus map map SNAI2@Nucleus map

As Catalyser:

  1. gBMI1@Nucleus map map rBMI1@Nucleus map

  2. gMDM2@Nucleus map map rMDM2@Nucleus map
  3. gHDAC1@Nucleus map map rHDAC1@Nucleus map
  4. gHDAC2@Nucleus map map rHDAC2@Nucleus map
  5. gSIN3A@Nucleus map map rSIN3A@Nucleus map
  6. gSNAI2@Nucleus map map rSNAI2@Nucleus map
  7. gTCF3@Nucleus map map rTCF3@Nucleus map
  8. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
  9. gE-Cadherin*@Nucleus map map rE-Cadherin*@Nucleus map
  10. gClaudin1*@Nucleus map map rClaudin1*@Nucleus map

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