SNAI1

RNA SNAI1 map

Identifiers
snail homolog 1
HUGO:SNAI1 HGNC:11128 ENTREZ:6615 UNIPROT:O95863 GENECARDS:SNAI1 KEGG:6615 ATLASONC:SNAI1ID452ch20q13 WIKI:SNAI1
Snail homologue 1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Survival  map  / HEDGEHOG  map

References
PMID:22024162
PMID:20713713

rSNAI1@Nucleus

References
e_re1( EMT  map ):
PMID:20731704
PMID:21317430
In NMuMG cells treated with TGFB1 Snail1 RNA and protein are induced 1 h after addition of the cytokine preceding Zeb1 up-regulation that requires 6–8 h.
Zeb1 gene expression is caused by increased RNA levels but also by enhanced protein stability and is markedly dependent on Snail1 because depletion of this protein prevents Zeb1 protein and RNA up-regulation
PMID:22406545
TGFB can activate both SNAI1 and SNAI2 and thus promote EMT via both SMAD-dependent and -independent pathways
PMID:16617148
Negative feedback by SNAI1 itself
PMID:17671186
KLF8 directly bound to the promotor of Snail and repressed Snail expression
PMID:17563753
Snail promoter is regulated positively by NFkB_p65
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
e_re8( EMT  map ):
PMID:16001073
RAC1B increases the cellular level of ROS, causing an upregulation of Snail rexpression and induction of EMT


Modifications:
In compartment: Nucleus
  1. rSNAI1@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. MIR34*:​SNAI1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. gSNAI1@Nucleus map map rSNAI1@Nucleus map

  2. rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2*@Nucleus map map rSNAI1@Nucleus map
  3. rSNAI1@Nucleus map map SNAI1@Nucleus map
  4. gSNAI1@Nucleus map map rSNAI1@Nucleus map
  5. rSNAI1@Nucleus map map EMT@Nucleus map

As Catalyser:

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