SMO

Protein SMO map

Identifiers
Smoothened
HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO

Maps_Modules
 Survival  map  / HEDGEHOG  map

References
PMID:18820483
PMID:17641202
Smoothened homologue (Drosophila)

SMO|​pho|​active@Primary Cilium

References
s_shh1_re38( Survival  map ):
PMID:20956384
PMID:21209912
PMID:19549984
PMID:19592253
s_shh1_re40( Survival  map ):
PMID:20643644
s_shh1_re52:( Survival  map ) PMID:20016067
s_shh1_re92:( Survival  map ) PMID:18997815
s_shh1_re101:( Survival  map ) PMID:17688959
s_s_shh1_re40( Survival  map ):

SMO|​pho|​active@Cytoplasm

References
s_shh1_re28:( Survival  map ) PMID:15618519
s_shh3_re8( Survival  map ):
PMID:18815277
PMID:16885213
s_shh1_re33:( Survival  map ) PMID:18497258
s_shh3_re13:( Survival  map ) PMID:12514186 PMID:18359851

SMO@Cytoplasm

References
s_shh1_re27:( Survival  map ) PMID:17430994
s_shh1_re28:( Survival  map ) PMID:15618519
s_shh2_re121( Survival  map ):
PMID:20564213
ANNOTATION: Not clear how suprresion is regulated by Hedgehog
s_shh2_re122:( Survival  map ) PMID:19351822
s_shh3_re8( Survival  map ):
PMID:18815277
PMID:16885213

SMO@Cytoplasm

Maps_Modules
 Survival  map  / HEDGEHOG  map

SMO|​pho|​active@Cytoplasm

Maps_Modules
 Survival  map  / HEDGEHOG  map


Modifications:
In compartment: Cytoplasm
  1. SMO@Cytoplasm map

  2. SMO@Cytoplasm map
  3. SMO@Cytoplasm map
  4. SMO|​pho|​active@Cytoplasm map
  5. SMO|​pho|​active@Cytoplasm map

In compartment: Primary Cilium

  1. SMO|​pho|​active@Primary Cilium map

Participates in complexes:
In compartment: Clathrin-coated vesicle

  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map

In compartment: Cytoplasm

  1. G_alpha__sub_i_endsub_*:​SMO@Cytoplasm map

  2. G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map
  3. G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map
  4. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​SMO@Cytoplasm map
  5. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map

In compartment: Primary Cilium

  1. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map

Participates in reactions:
As Reactant or Product:

  1. HH Ligand:​PTCH*@Cytoplasm map + G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​SMO@Cytoplasm map + GTP@Cytoplasm map map G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map + GDP@Cytoplasm map

  2. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map map HH Ligand:​PTCH*@Cytoplasm map + SMO@Cytoplasm map + s_s_shh1_s589 + G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytoplasm map
  3. SMO@Cytoplasm map map SMO|​pho|​active@Cytoplasm map
  4. SMO|​pho|​active@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map + KIF3A:​KIF3B@Cytoplasm map map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map
  5. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map map _beta_-Arrestin2*@Primary Cilium map + SMO|​pho|​active@Primary Cilium map + KIF3A:​KIF3B@Primary Cilium map
  6. KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Clathrin-coated vesicle map map KIF3A:​KIF3B:​SMO|​pho:​_beta_-Arrestin2*@Primary Cilium map
  7. G_alpha__sub_i_endsub_*:​SMO@Cytoplasm map + Ligand:​PTCH*@Cytoplasm map map G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map
  8. G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map + GTP@Cytoplasm map map G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map + GDP@Cytoplasm map
  9. G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map map PTCH*@Cytoplasm map + s_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytoplasm map + SMO@Cytoplasm map
  10. SMO@Cytoplasm map map SMO|​pho|​active@Cytoplasm map
  11. SMO|​pho|​active@Cytoplasm map map Sonic hedgehog pathway@Cytoplasm map

As Catalyser:

  1. AKT*|​pho|​T450_pho:​PI3,4,5-P3@Cytoplasm map map AKT*|​pho|​T450_pho|​pho:​PI3,4,5-P3@Cytoplasm map

  2. GLI2-185*:​KIF7:​SUFU:​ULK3@Cytoplasm map map GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map
  3. GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Cytoplasm map map GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Primary Cilium map
  4. GLI2-185*:​KIF7:​SUFU:​ULK3@Primary Cilium map map SUFU@Primary Cilium map + GLI2-185*@Primary Cilium map + KIF7@Primary Cilium map + ULK3@Primary Cilium map
  5. GLI3-190*|​S849_emp:​KIF7:​SUFU:​ULK3@Primary Cilium map map SUFU@Primary Cilium map + GLI3-190*|​S849_emp|​active@Primary Cilium map + KIF7@Primary Cilium map + ULK3@Primary Cilium map
  6. AKAP*@Primary Cilium map + PKA*@Primary Cilium map map AKAP*:​PKA*@Primary Cilium map
  7. SUFU@Cytoplasm map map SUFU|​K257_ubi@Cytoplasm map
  8. gMIR29B*@Nucleus map map arMIR29B*@Nucleus map
  9. gMIR378@Nucleus map map arMIR378@Nucleus map
  10. C-FES*@Cytoplasm map map C-FES*@Cytoplasm map

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