SMAD3:SMAD4:SP1

Complex SMAD3:SMAD4:SP1 map


Complex composition:

  1. SP1 map
  2. SMAD4 map
  3. SMAD3 map




SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SP1@Nucleus

Identifiers
NAME:SMAD3:SMAD4:SP1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re275( EMT  map ):
PMID:9618481
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
PMID:12545156
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
PMID:15155580
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
PMID:17550342
SNAI2 induces p21CIP1 (CDKN1A) expression
e_re283( EMT  map ):
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression

Confidence
REF=4 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SP1@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4)|​active@Nucleus map + SP1@Nucleus map map SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SP1@Nucleus map

As Catalyser:

  1. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map

  2. gCOL1A2@Nucleus map map rCOL1A2@Nucleus map

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