SIN3A

Protein SIN3A map

Identifiers
SIN3 transcription regulator homolog A (yeast)
SIN3A
HUGO:SIN3A HGNC:19353 ENTREZ:25942 UNIPROT:Q96ST3 GENECARDS:SIN3A REACTOME:101853 ATLASONC:GC_SIN3A WIKI:SIN3A

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:14673164
Snail interacts in vivo with the E-cadherin promoter and recruits HDAC activity.
Interaction between Snail, HDAC1 and HDAC2, and the corepressor Sin3A is dependent on the SNAG domain of Snail, indicating that the Snail transcription factor mediates the repression by recruitment of chromatin-modifying activities, forming a multimolecular complex to repress E-cadherin expression.

SIN3A@Nucleus

References
e_re1184( EMT  map ):
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:14673164
Snail interacts in vivo with the E-cadherin promoter and recruits HDAC activity.
Interaction between Snail, HDAC1 and HDAC2, and the corepressor Sin3A is dependent on the SNAG domain of Snail, indicating that the Snail transcription factor mediates the repression by recruitment of chromatin-modifying activities, forming a multimolecular complex to repress E-cadherin expression.


Modifications:
In compartment: Nucleus
  1. SIN3A@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. CBF1*:​CIR1:​HDAC2:​SIN3A@Nucleus map

  2. HDAC1:​HDAC2:​SIN3A:​SNAI1@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. SNAI1@Nucleus map + HDAC1@Nucleus map + HDAC2@Nucleus map + SIN3A@Nucleus map map HDAC1:​HDAC2:​SIN3A:​SNAI1@Nucleus map

  2. rSIN3A@Nucleus map map SIN3A@Nucleus map
  3. CBF1*@Nucleus map + CIR1@Nucleus map + SIN3A@Nucleus map + HDAC2@Nucleus map map CBF1*:​CIR1:​HDAC2:​SIN3A@Nucleus map

As Catalyser:

  1. gE-Cadherin*@Nucleus map map rE-Cadherin*@Nucleus map

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