SHC1_p66_p52*

Protein SHC1_p66_p52* map

Identifiers
SHC (Src homology 2 domain containing) transforming protein 1
HUGO:SHC1 HGNC:10840 ENTREZ:6464 UNIPROT:P29353 GENECARDS:SHC1 REACTOME:64430 KEGG:6464 ATLASONC:SHC1ID42287ch1q21 WIKI:SHC1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos

SHC1_p66_p52*@Cytoplasm

References
e_re1272( EMT  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation

SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm

References
e_re1272( EMT  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation
e_re1275( EMT  map ):
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos


Modifications:
In compartment: Cytoplasm
  1. SHC1_p66_p52*@Cytoplasm map

  2. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. EGFR family*|​pho|​hm2:​GRB2:​SHC1_p66_p52*|​Y_pho|​S_pho:​SOS*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. SHC1_p66_p52*@Cytoplasm map map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map

  2. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytoplasm map + EGF family*:​EGFR family*|​pho|​hm2@Cytoplasm map + SOS*@Cytoplasm map + GRB2@Cytoplasm map map EGFR family*|​pho|​hm2:​GRB2:​SHC1_p66_p52*|​Y_pho|​S_pho:​SOS*@Cytoplasm map

As Catalyser:

  1. GDP:​HRAS@Cytoplasm map map GTP:​HRAS@Cytoplasm map

Leave a Reply