SDHA

Protein SDHA map

Identifiers
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
HUGO:SDHA HGNC:10680 ENTREZ:6389 UNIPROT:P31040 GENECARDS:SDHA REACTOME:53638 KEGG:6389 ATLASONC:GC_SDHA WIKI:SDHA

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

References
FAD cofactor binding

SDHA@Mitochondrial inner membrane

References
a_re64( Apoptosis  map ):
PMID:19628817
SDH5 is required for SDHA flavination (inferred from yeast)
SDH5 primarily soluble and localized in mitochondrial matrix (inferred from yeast)
SDH5 mutation segregates with disease in a family with paraganglioma


Modifications:
In compartment: Mitochondrial inner membrane
  1. SDHA@Mitochondrial inner membrane map

Participates in complexes:
In compartment: Mitochondrial inner membrane

  1. FAD:​SDHA@Mitochondrial inner membrane map

  2. FAD:​SDHA:​SDHB|​[2Fe-2S],[4Fe-4S],[3Fe-4S]:​SDHC:​SDHD:​cardiolipin:​heme b:​phosphatidylethanolamine@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. SDHA@Mitochondrial inner membrane map + FAD@Mitochondrial inner membrane map map FAD:​SDHA@Mitochondrial inner membrane map

  2. degraded + FAD:​SDHA@Mitochondrial inner membrane map + SDHB@Mitochondrial inner membrane map + SDHC@Mitochondrial inner membrane map + SDHD@Mitochondrial inner membrane map map FAD:​SDHA:​SDHB|​[2Fe-2S],[4Fe-4S],[3Fe-4S]:​SDHC:​SDHD:​cardiolipin:​heme b:​phosphatidylethanolamine@Mitochondrial inner membrane map

As Catalyser:

  1. succinate@Mitochondrial Matrix map + ubiquinone@Mitochondrial inner membrane map map fumarate@Mitochondrial Matrix map + ubiquinol@Mitochondrial inner membrane map

Leave a Reply