SARA*:TGFB1:TGFBR1:TGFBR2

Complex SARA*:TGFB1:TGFBR1:TGFBR2 map


Complex composition:

  1. TGFBR2 map
  2. TGFB1 map
  3. TGFBR1 map
  4. SARA* map




SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome

Identifiers
NAME:SARA*:TGFB1:TGFBR1:TGFBR2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re249( EMT  map ):
PMID:9865696
SARA interacts directly with Smad2 and Smad3
The C-ter of SARA interacts TGFBR1 and TGFBR2
SARA presents Smad2 to the TGFb receptor
Phosphorylation of Smad2 induces dissociation from SARA with concomitant formation of Smad2-Smad4 complexes and nuclear translocation.
PMID:12154066
Small GTPases such as Rab5 catalyse movement of activated receptor complexes to early endosomal compartments
Here, the complex encounter SARA: a phospholipid-bound carrier
SARA presents Smads to the TGFBR1
PMID:22710166
PMID:11013220
The ligand bound activated receptor complex is internalized via endocytosis
PMID:19050695
2 pathways of receptor complex endocytosis: clathrin-mediated or caveolae-mediated
Through the clathrin pathway, activated ligan-receptor complex are brought into early endosomes which are enriched with scaffold proteins such as SARA.
PMID:12717440
PMID:12724770
Clathrin-dependent internalization into endosome, where the Smad2 anchor SARA is enriched, promotes TGFB signalling.
Raft-caveolar internalization pathway contains the Smad7-Smurf2 bound receptor and is required for rapid receptor turnover.
Thus, segregation of TGF-b receptors into distinct endocytic compartments regulates Smad activation and receptor turnover
e_re217( EMT  map ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: Early Endosome
  1. SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome map

Participates in reactions:
As Reactant or Product:

  1. SARA*@Early Endosome map + TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytoplasm map map SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome map

As Catalyser:

  1. SARA*:​SMAD2@Early Endosome map + ATP@Cytoplasm map map SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome map + ADP@Cytoplasm map

  2. SARA*:​SMAD3@Early Endosome map + ATP@Cytoplasm map map SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map + ADP@Cytoplasm map

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