SARA*:SMAD2

Complex SARA*:SMAD2 map


Complex composition:

  1. SARA* map
  2. SMAD2 map




SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome

Identifiers
NAME:SARA*:SMAD2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re217( EMT  map ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3
e_re218( EMT  map ):
PMID:9865696
Phosphorylation of Smad2 induces dissociation from SARA
with concomitant formation of Smad2/ Smad4 complexes
and nuclear translocation.

Confidence
REF=2 FUNC=5

SARA*:​SMAD2@Early Endosome

Identifiers
NAME:SARA*:SMAD2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re216( EMT  map ):
PMID:9865696
SARA interacts directly with Smad2 and Smad3
PMID:11792802
SARA is a cytoplasmic protein that specifically interacts withe no-activated Smad2 and the receptor complex
SARA thus forms the bridge between the receptor and Smad2 and assisting in the specific phosphorylation of Smad2 by the TGFBR1
The stable interaction of SARA with non-phosphorylated Smad2 also inhibits nuclear import of Smad2
PMID:10934479
The nuclear import function of Smad2 is masked by SARA and unmasked by TGFB- dependent phosphorylation
e_re217( EMT  map ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3

Confidence
REF=3 FUNC=5


Modifications:
Participates in complexes:
In compartment: Early Endosome
  1. SARA*:​SMAD2@Early Endosome map

  2. SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome map

Participates in reactions:
As Reactant or Product:

  1. SMAD2@Cytoplasm map + SARA*@Early Endosome map map SARA*:​SMAD2@Early Endosome map

  2. SARA*:​SMAD2@Early Endosome map + ATP@Cytoplasm map map SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome map + ADP@Cytoplasm map
  3. SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome map map SMAD2|​S467_pho|​S465_pho@Cytoplasm map + SARA*@Early Endosome map

As Catalyser:

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