Reaction heterodimer_association s_s_wnc2_re45
(NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*)|active@Cytoplasm + KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
No reaction regulators
Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT.
TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex