s_s_wca1_re36

Reaction state_transition s_s_wca1_re36 map

AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

Reaction regulators:

Catalysis
  1. CyclinY*:​PFTK*@Cytoplasm map



Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573
ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A
ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand
WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M

Confidence
REF=2 FUNC=3


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