s_s_mpk1_re9

Reaction heterodimer_association s_s_mpk1_re9 map

RAS*@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Reaction regulators:

Catalysis
  1. SPRY2|​pho@Cytoplasm map
  2. SPRY1|​pho@Cytoplasm map



References
Sos mediates Ras activation. Interaction of Sos with Ras induces the formation of RasGTP from RasGDP.
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:17496910 PMID:15173823

Confidence
REF=0 FUNC=4


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