s_s_mpk1_re35

Reaction dissociation s_s_mpk1_re35 map

IMP*:​KSR1:​MEK*@Cytoplasm map IMP*@Cytoplasm map + KSR1:​MEK*@Cytoplasm map

Reaction regulators:

Unknown_catalysis
  1. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map



References
RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade.
Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2.
PMID:14724641 PMID:17496910

Confidence
REF=1 FUNC=4


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