s_s_mpk1_re279

Reaction state_transition s_s_mpk1_re279 map

MYC@Nucleus map Proliferation@Cytoplasm map

Reaction regulators:

Catalysis
  1. MAX|​pho@Cytoplasm map
Inhibition
  1. GSK3_beta_*@Cytoplasm map



References
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes.
GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation.
PMID:11274345 PMID:12040186

Confidence
REF=0 FUNC=5


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