s_s_mpk1_re21

Reaction heterodimer_association s_s_mpk1_re21 map

RAF1@Cytoplasm map + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

Reaction regulators:

Unknown_catalysis
  1. SUR-8*@Cytoplasm map



References
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK map signalling pathway.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19289794 PMID:17496910

Confidence
REF=1 FUNC=4


Leave a Reply