s_s_mpk1_re193

Reaction dissociation s_s_mpk1_re193 map

ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map

Reaction regulators:

Catalysis
  1. ATF2|​pho:​JUN|​pho@Nucleus map
  2. s_s_mpk1_s1051
  3. FOS|​pho:​JUN|​pho@Nucleus map
  4. p38*|​pho|​pho@Cytoplasm map
  5. PP2A_C*|​unk@Cytoplasm map



References
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

Confidence
REF=0 FUNC=4


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