Reaction dissociation s_s_mpk1_re193
ERK*|pho|pho:GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes → GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes + ERK*@Cytoplasm + RAF1@Cytoplasm
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.