Reaction dissociation s_s_mpk1_re192
ERK*|pho|pho:MEK*|pho|pho:_beta_-Arrestin2*@Early Endosomes → MEK*:_beta_-Arrestin2*@Cytoplasm + ERK*@Cytoplasm
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.