Reaction heterodimer_association s_s_mpk1_re19
GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + LAMTOR2:MEK*:MP1*@Late Endosomes → GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes
No reaction regulators
Transfer of activated RTK/Grb2/Sos/RasGTP complex to late endosomes where it binds P14/MP1/MEK1 complex allowing the ERK cascade.
Upon EGF stimulation EGFR in complex with Grb2 is endocytosed and transported to late endosomes with Grb2-binding proteins such as Sos resulting in the activation of KRas on late endosomes.