s_s_mpk1_re187

Reaction state_transition s_s_mpk1_re187 map

ERK*|​pho|​pho@Cytoplasm map ERK*@Cytoplasm map

Reaction regulators:

Catalysis
  1. ATF2|​pho:​JUN|​pho@Nucleus map
  2. s_s_mpk1_s1051
  3. FOS|​pho:​JUN|​pho@Nucleus map
  4. p38*|​pho|​pho@Cytoplasm map
  5. JUN|​pho@Nucleus map



References
JNK pathway negatively regulates ERK pathway by uncoupling ERK activation from MEK via activation of JUN transcriptional activity.
A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:12738796 PMID:18039929

Confidence
REF=1 FUNC=4


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