s_s_mpk1_re186

Reaction state_transition s_s_mpk1_re186 map

MEK*@Cytoplasm map MEK*|​pho|​pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. MAP3K10_11*|​pho:​RAC1|​pho:​RTK*@Cytoplasm map
  2. MAP3K2_3*|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  3. MAP3K2_3*|​pho:​TNFRSF1B@Cytoplasm map
  4. s_s_mpk1_s1049
  5. RAF1|​pho@Cytoplasm map



References
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways
MLK3 has the potential to positively regulate the ERK pathway by directly phosphorylating and activating MEK.
PMID:11274345 PMID:12738796

Confidence
REF=1 FUNC=4


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