s_s_mpk1_re147

Reaction heterodimer_association s_s_mpk1_re147 map

RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map → s_s_mpk1_s1048

No reaction regulators

References
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12655147

Confidence
REF=0 FUNC=5


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