Reaction heterodimer_association s_s_mpk1_re13
GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + BRAF@Cytoplasm → BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high aﬃnity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910