s_s_mpk1_re13

Reaction heterodimer_association s_s_mpk1_re13 map

GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + BRAF@Cytoplasm map BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Reaction regulators:

Unknown_catalysis
  1. SUR-8*@Cytoplasm map



References
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high affinity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910

Confidence
REF=1 FUNC=4


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