s_s_mpk1_re118

Reaction state_transition s_s_mpk1_re118 map

BAD@Mitochondria map BAD|​pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. RAF1|​pho@Mitochondria map



References
A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release.
PMID:12107820

Confidence
REF=0 FUNC=5


Leave a Reply