S_PHASE_CHECKPOINT

MAP:DNA_REPAIR/MODULE:S_PHASE_CHECKPOINT map
The propagation of cell cycle is arrested by this checkpoint to ensure complete DNA replication. DNA damage may occur during the replication due to mistakes of nucleotides incorporation, recombination mistakes, stalled replication fork or external damage.
The DNA repair machinery is active during this phase to remove singe and double strand breaks and resolve the stalled replication fork. This is the stage where HR is active for accurate double strand repair.
PMID:17102137
PMID:17116885
PMID:17296725
PMID:19793801
PMID:17582221
PMID:18677104
======== References ========
PMID:7575488 Nigg EA (1995) Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17(6);471-80.
PMID:8943031 Lieberman HB, Hopkins KM, Nass M, Demetrick D, Davey S (1996) A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Proc. Natl. Acad. Sci. U.S.A. 93(24);13890-5.
PMID:9168117 Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF (1997) Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387(6632);520-3.
PMID:9346961 Ford JM, Hanawalt PC (1997) Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J. Biol. Chem. 272(44);28073-80.
PMID:9407949 Yacoub A, Kelley MR, Deutsch WA (1998) The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation. Cancer Res. 57(24);5457-9.
PMID:9488723 Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273(10);5858-68.
PMID:9524127 Kostrub CF, Knudsen K, Subramani S, Enoch T (1998) Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J. 17(7);2055-66.
PMID:9721205 Fusco C, Reymond A, Zervos AS (1998) Molecular cloning and characterization of a novel retinoblastoma-binding protein. Genomics 51(3);351-8.
PMID:9858600 Sewalt RG, Gunster MJ, van der Vlag J, Satijn DP, Otte AP (1998) C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19(1);777-87.
PMID:9892649 Hwang BJ, Ford JM, Hanawalt PC, Chu G (1999) Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl. Acad. Sci. U.S.A. 96(2);424-8.
PMID:10367887 Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA (1999) Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97(5);575-86.
PMID:10779360 Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, Deng CX, Hanawalt PC, Fornace AJ (2000) p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol. Cell. Biol. 20(10);3705-14.
PMID:10882712 Kuraoka I, Kobertz WR, Ariza RR, Biggerstaff M, Essigmann JM, Wood RD (2000) Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease. J. Biol. Chem. 275(34);26632-6.
PMID:10884389 MacLachlan TK, Dash BC, Dicker DT, El-Deiry WS (2000) Repression of BRCA1 through a feedback loop involving p53. J. Biol. Chem. 275(41);31869-75.
PMID:10884395 Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000) The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. J. Biol. Chem. 275(38);29767-71.
PMID:10921877 Hrimech M, Yao XJ, Branton PE, Cohen EA (2000) Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. EMBO J. 19(15);3956-67.
PMID:10962562 Jin S, Zhao H, Fan F, Blanck P, Fan W, Colchagie AB, Fornace AJ, Zhan Q (2000) BRCA1 activation of the GADD45 promoter. Oncogene 19(35);4050-7.
PMID:11438669 Amin NS, Nguyen MN, Oh S, Kolodner RD (2001) exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol. Cell. Biol. 21(15);5142-55.
PMID:11804596 Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole PA, Fontemaggi G, Fanciulli M, Schiltz L, Blandino G, Balsano C, Levrero M (2002) DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9(1);175-86.
PMID:11850621 Falck J, Petrini JH, Williams BR, Lukas J, Bartek J (2002) The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30(3);290-4.
PMID:11877377 Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16(5);571-82.
PMID:11900249 Friedberg EC (2002) How nucleotide excision repair protects against cancer. Nat. Rev. Cancer 1(1);22-33.
PMID:11971963 Yoshida K, Komatsu K, Wang HG, Kufe D (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol. 22(10);3292-300.
PMID:12024039 MacLachlan TK, Takimoto R, El-Deiry WS (2002) BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. Mol. Cell. Biol. 22(12);4280-92.
PMID:12086603 Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D’Andrea AD (2002) Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109(4);459-72.
PMID:12170778 Takimoto R, MacLachlan TK, Dicker DT, Niitsu Y, Mori T, el-Deiry WS (2002) BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation. Cancer Biol. Ther. 1(2);177-86.
PMID:12370081 Zhou J, Pham HT, Ruediger R, Walter G (2002) Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Biochem. J. 369(Pt 2);387-98.
PMID:12466554 Frank EG, Sayer JM, Kroth H, Ohashi E, Ohmori H, Jerina DM, Woodgate R (2002) Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. Nucleic Acids Res. 30(23);5284-92.
PMID:12496474 El-Deiry WS (2002) Transactivation of repair genes by BRCA1. Cancer Biol. Ther. 1(5);490-1.
PMID:12556884 Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421(6922);499-506.
PMID:12607003 Goldberg M, Stucki M, Falck J, D’Amours D, Rahman D, Pappin D, Bartek J, Jackson SP (2003) MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421(6926);952-6.
PMID:12628935 Yoshida K, Wang HG, Miki Y, Kufe D (2003) Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J. 22(6);1431-41.
PMID:12648680 Mitchell JR, Hoeijmakers JH, Niedernhofer LJ (2003) Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr. Opin. Cell Biol. 15(2);232-40.
PMID:12709442 Roos-Mattjus P, Hopkins KM, Oestreich AJ, Vroman BT, Johnson KL, Naylor S, Lieberman HB, Karnitz LM (2003) Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling. J. Biol. Chem. 278(27);24428-37.
PMID:12766152 Chini CC, Chen J (2003) Human claspin is required for replication checkpoint control. J. Biol. Chem. 278(32);30057-62.
PMID:12771027 Fitch ME, Cross IV, Ford JM (2003) p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo. Carcinogenesis 24(5);843-50.
PMID:12875843 Gotter AL (2003) Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J. Mol. Biol. 331(1);167-76.
PMID:14614141 Cortellino S, Turner D, Masciullo V, Schepis F, Albino D, Daniel R, Skalka AM, Meropol NJ, Alberti C, Larue L, Bellacosa A (2003) The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc. Natl. Acad. Sci. U.S.A. 100(25);15071-6.
PMID:14657033 Guo C, Fischhaber PL, Luk-Paszyc MJ, Masuda Y, Zhou J, Kamiya K, Kisker C, Friedberg EC (2003) Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J. 22(24);6621-30.
PMID:14726013 Fortini P, Pascucci B, Parlanti E, D’Errico M, Simonelli V, Dogliotti E (2004) The base excision repair: mechanisms and its relevance for cancer susceptibility. Biochimie 85(11);1053-71.
PMID:14871926 Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, Abraham RT, Wang XF (2004) Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev. 18(3);249-54.
PMID:14988723 Pichierri P, Rosselli F (2004) The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 23(5);1178-87.
PMID:15136767 Pichierri P, Rosselli F (2004) Fanconi anemia proteins and the s phase checkpoint. Cell Cycle 3(6);698-700.
PMID:15175241 Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB (2004) Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18(12);1423-38.
PMID:15189446 Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H (2004) Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells 9(6);523-31.
PMID:15211575 Perrault R, Wang H, Wang M, Rosidi B, Iliakis G (2004) Backup pathways of NHEJ are suppressed by DNA-PK. J. Cell. Biochem. 92(4);781-94.
PMID:15220350 Xu X, Lee J, Stern DF (2004) Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J. Biol. Chem. 279(33);34091-4.
PMID:15242590 Botuyan MV, Nomin– Y, Yu X, Juranic N, Macura S, Chen J, Mer G (2004) Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12(7);1137-46.
PMID:15279786 Lukas J, Lukas C, Bartek J (2004) Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst.) 3(8-9);997-1007.
PMID:15375219 Daniels MJ, Wang Y, Lee M, Venkitaraman AR (2004) Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 306(5697);876-9.
PMID:15377654 Freie BW, Ciccone SL, Li X, Plett PA, Orschell CM, Srour EF, Hanenberg H, Schindler D, Lee SH, Clapp DW (2004) A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. J. Biol. Chem. 279(49);50986-93.
PMID:15459660 Bartek J, Lukas C, Lukas J (2004) Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5(10);792-804.
PMID:15485915 Yu X, Chen J (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol. Cell. Biol. 24(21);9478-86.
PMID:15496928 Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, Carotenuto W, Liberi G, Bressan D, Wan L, Hollingsworth NM, Haber JE, Foiani M (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431(7011);1011-7.
PMID:15498778 Audebert M, Salles B, Calsou P (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem. 279(53);55117-26.
PMID:15549137 Aylon Y, Liefshitz B, Kupiec M (2004) The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 23(24);4868-75.
PMID:15650050 Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D’Andrea AD, Wang ZQ, Jasin M (2005) Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc. Natl. Acad. Sci. U.S.A. 102(4);1110-5.
PMID:15655342 Aylon Y, Kupiec M (2005) Cell cycle-dependent regulation of double-strand break repair: a role for the CDK. Cell Cycle 4(2);259-61.
PMID:15703371 Zheng P, Schramm RD, Latham KE (2005) Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos. Biol. Reprod. 72(6);1359-69.
PMID:15743907 Ball HL, Myers JS, Cortez D (2005) ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 16(5);2372-81.
PMID:15798197 Unsal-Ka–maz K, Mullen TE, Kaufmann WK, Sancar A (2005) Coupling of human circadian and cell cycles by the timeless protein. Mol. Cell. Biol. 25(8);3109-16.
PMID:15810020 Bogdanova N, Enssen-Dubrowinskaja N, Feshchenko S, Lazjuk GI, Rogov YI, Dammann O, Bremer M, Karstens JH, Sohn C, D–rk T (2005) Association of two mutations in the CHEK2 gene with breast cancer. Int. J. Cancer 116(2);263-6.
PMID:15867354 El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S (2005) Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Res. 65(9);3604-9.
PMID:15871698 Smirnova E, Toueille M, Markkanen E, H–bscher U (2005) The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochem. J. 389(Pt 1);13-7.
PMID:15964794 You Z, Chahwan C, Bailis J, Hunter T, Russell P (2005) ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25(13);5363-79.
PMID:16163361 Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C (2005) Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature 437(7057);440-3.
PMID:16216273 Friedrich-Heineken E, Toueille M, T–nnler B, B–rki C, Ferrari E, Hottiger MO, H–bscher U (2005) The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. J. Mol. Biol. 353(5);980-9.
PMID:16260606 Zhang J, Bao S, Furumai R, Kucera KS, Ali A, Dean NM, Wang XF (2005) Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Mol. Cell. Biol. 25(22);9910-9.
PMID:16310392 Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J (2005) gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 20(5);801-9.
PMID:16332722 O’Brien V, Brown R (2005) Signalling cell cycle arrest and cell death through the MMR System. Carcinogenesis 27(4);682-92.
PMID:16337602 Kawamoto T, Araki K, Sonoda E, Yamashita YM, Harada K, Kikuchi K, Masutani C, Hanaoka F, Nozaki K, Hashimoto N, Takeda S (2005) Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol. Cell 20(5);793-9.
PMID:16377563 Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123(7);1213-26.
PMID:16449207 Harrigan JA, Wilson DM, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA (2006) The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res. 34(2);745-54.
PMID:16530042 Kumagai A, Lee J, Yoo HY, Dunphy WG (2006) TopBP1 activates the ATR-ATRIP complex. Cell 124(5);943-55.
PMID:16531125 Stucki M, Jackson SP (2006) gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst.) 5(5);534-43.
PMID:16540648 Wu X, Shell SM, Yang Z, Zou Y (2006) Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res. 66(6);2997-3005.
PMID:16581787 Liu F, Lee WH (2006) CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol. Cell. Biol. 26(8);3124-34.
PMID:16697054 Ding J, Miao ZH, Meng LH, Geng MY (2006) Emerging cancer therapeutic opportunities target DNA-repair systems. Trends Pharmacol. Sci. 27(6);338-44.
PMID:16705156 Gil-Bernab– AM, Romero F, Lim–n-Mort–s MC, Tortolero M (2006) Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase. Mol. Cell. Biol. 26(11);4017-27.
PMID:16713580 Yoshioka K, Yoshioka Y, Hsieh P (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22(4);501-10.
PMID:16731526 Wang W, Lindsey-Boltz LA, Sancar A, Bambara RA (2006) Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. J. Biol. Chem. 281(30);20865-72.
PMID:16731533 Guo S, Zhang Y, Yuan F, Gao Y, Gu L, Wong I, Li GM (2006) Regulation of replication protein A functions in DNA mismatch repair by phosphorylation. J. Biol. Chem. 281(31);21607-16.
PMID:16805667 Harrison JC, Haber JE (2006) Surviving the breakup: the DNA damage checkpoint. Annu. Rev. Genet. 40;209-35.
PMID:16818604 Yu X, Fu S, Lai M, Baer R, Chen J (2006) BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev. 20(13);1721-6.
PMID:16824193 Yuasa MS, Masutani C, Hirano A, Cohn MA, Yamaizumi M, Nakatani Y, Hanaoka F (2006) A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells 11(7);731-44.
PMID:16858402 Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25(15);3504-14.
PMID:16879101 Shi G, Chang DY, Cheng CC, Guan X, Venclovas C, Lu AL (2006) Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. Biochem. J. 400(1);53-62.
PMID:16880517 Liu S, Bekker-Jensen S, Mailand N, Lukas C, Bartek J, Lukas J (2006) Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol. Cell. Biol. 26(16);6056-64.
PMID:16885023 Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L (2006) Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell 23(3);331-41.
PMID:16885030 Leulliot N, Vicentini G, Jordens J, Quevillon-Cheruel S, Schiltz M, Barford D, van Tilbeurgh H, Goris J (2006) Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. Mol. Cell 23(3);413-24.
PMID:16916641 Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y (2006) Structure and mechanism of the phosphotyrosyl phosphatase activator. Mol. Cell 23(4);535-46.
PMID:16934469 Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R (2006) Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr. Biol. 16(19);1950-5.
PMID:17035102 Sabbioneda S, Bortolomai I, Giannattasio M, Plevani P, Muzi-Falconi M (2006) Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1. DNA Repair (Amst.) 6(1);121-7.
PMID:17036055 Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, Kanaar R (2006) The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J. 25(20);4921-32.
PMID:17102137 Yoshizawa-Sugata N, Masai H (2006) Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J. Biol. Chem. 282(4);2729-40.
PMID:17116885 Chou DM, Elledge SJ (2006) Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. U.S.A. 103(48);18143-7.
PMID:17141802 Gotter AL, Suppa C, Emanuel BS (2006) Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J. Mol. Biol. 366(1);36-52.
PMID:17296725 Unsal-Ka–maz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (2007) The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell. Biol. 27(8);3131-42.
PMID:17296736 Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D’Andrea AD (2007) Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 27(8);3098-108.
PMID:17303408 Bartek J, Lukas J (2007) DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opin. Cell Biol. 19(2);238-45.
PMID:17384638 Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ (2007) HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat. Cell Biol. 9(4);391-401.
PMID:17395641 Guan X, Bai H, Shi G, Theriot CA, Hazra TK, Mitra S, Lu AL (2007) The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase. Nucleic Acids Res. 35(8);2463-72.
PMID:17426133 Gembka A, Toueille M, Smirnova E, Poltz R, Ferrari E, Villani G, H–bscher U (2007) The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair. Nucleic Acids Res. 35(8);2596-608.
PMID:17464182 Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J (2007) Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Exp. Mol. Med. 39(2);205-12.
PMID:17493829 Singh VK, Nurmohamed S, Davey SK, Jia Z (2007) Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex. Protein Expr. Purif. 54(2);204-11.
PMID:17568790 Boutros R, Lobjois V, Ducommun B (2007) CDC25 phosphatases in cancer cells: key players? Good targets? Nat. Rev. Cancer 7(7);495-507.
PMID:17582221 Kaufmann WK (2007) Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Cell Cycle 6(12);1460-7.
PMID:17660363 De Souza CP, Osmani SA (2007) Mitosis, not just open or closed. Eukaryotic Cell 6(9);1521-7.
PMID:17713585 Williams RS, Williams JS, Tainer JA (2007) Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 85(4);509-20.
PMID:17855402 Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL (2007) The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase. Nucleic Acids Res. 35(18);6207-18.
PMID:17884153 Saldivar JS, Wu X, Follen M, Gershenson D (2007) Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity. Gynecol. Oncol. 107(1 Suppl 1);S56-71.
PMID:17965729 Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (2007) Human CtIP promotes DNA end resection. Nature 450(7169);509-14.
PMID:18001825 Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J (2007) RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131(5);901-14.
PMID:18006705 Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D (2007) Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318(5856);1637-40.
PMID:18048416 El-Shemerly M, Hess D, Pyakurel AK, Moselhy S, Ferrari S (2007) ATR-dependent pathways control hEXO1 stability in response to stalled forks. Nucleic Acids Res. 36(2);511-9.
PMID:18087292 Lieber MR, Lu H, Gu J, Schwarz K (2007) Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system. Cell Res. 18(1);125-33.
PMID:18157158 Andersen PL, Xu F, Xiao W (2007) Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 18(1);162-73.
PMID:18171670 Chen L, Nievera CJ, Lee AY, Wu X (2008) Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J. Biol. Chem. 283(12);7713-20.
PMID:18171986 Wu M, Soler DR, Abba MC, Nunez MI, Baer R, Hatzis C, Llombart-Cussac A, Llombart-Bosch A, Aldaz CM (2008) CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol. Cancer Res. 5(12);1285-95.
PMID:18212739 Wilson JB, Yamamoto K, Marriott AS, Hussain S, Sung P, Hoatlin ME, Mathew CG, Takata M, Thompson LH, Kupfer GM, Jones NJ (2008) FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene 27(26);3641-52.
PMID:18398454 Muftuoglu M, Kusumoto R, Speina E, Beck G, Cheng WH, Bohr VA (2008) Acetylation regulates WRN catalytic activities and affects base excision DNA repair. PLoS ONE 3(4);e1918.
PMID:18451105 Yang XH, Shiotani B, Classon M, Zou L (2008) Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 22(9);1147-52.
PMID:18469862 Bae JB, Mukhopadhyay SS, Liu L, Zhang N, Tan J, Akhter S, Liu X, Shen X, Li L, Legerski RJ (2008) Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene 27(37);5045-56.
PMID:18511906 Zierhut C, Diffley JF (2008) Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J. 27(13);1875-85.
PMID:18543256 Liu A, Yoshioka K, Salerno V, Hsieh P (2008) The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine. J. Cell. Biochem. 105(1);245-54.
PMID:18566216 Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J (2008) Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. Mol. Cancer Ther. 7(6);1440-9.
PMID:18583988 Chapman JR, Jackson SP (2008) Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep. 9(8);795-801.
PMID:18584027 Bennardo N, Cheng A, Huang N, Stark JM (2008) Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 4(6);e1000110.
PMID:18590585 Abukhdeir AM, Park BH (2008) P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 10;e19.
PMID:18660752 Yang SZ, Lin FT, Lin WC (2008) MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep. 9(9);907-15.
PMID:18677104 Grallert B, Boye E (2008) The multiple facets of the intra-S checkpoint. Cell Cycle 7(15);2315-20.
PMID:18678709 Postow L, Ghenoiu C, Woo EM, Krutchinsky AN, Chait BT, Funabiki H (2008) Ku80 removal from DNA through double strand break-induced ubiquitylation. J. Cell Biol. 182(3);467-79.
PMID:18678890 Wu L, Luo K, Lou Z, Chen J (2008) MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc. Natl. Acad. Sci. U.S.A. 105(32);11200-5.
PMID:18716619 Huertas P, Cort–s-Ledesma F, Sartori AA, Aguilera A, Jackson SP (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455(7213);689-92.
PMID:18756267 Morin I, Ngo HP, Greenall A, Zubko MK, Morrice N, Lydall D (2008) Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J. 27(18);2400-10.
PMID:18809224 McVey M, Lee SE (2008) MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings. Trends Genet. 24(11);529-38.
PMID:18931676 Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M (2008) FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat. Struct. Mol. Biol. 15(11);1138-46.
PMID:18971944 Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY, Shen CY (2008) Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 27(23);3140-50.
PMID:18995830 Collis SJ, Ciccia A, Deans AJ, Horejs– Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell 32(3);313-24.
PMID:19004803 Auclair Y, Rouget R, Affar el B, Drobetsky EA (2008) ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells. Proc. Natl. Acad. Sci. U.S.A. 105(46);17896-901.
PMID:19075565 Kiyokawa H, Ray D (2009) In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets. Anticancer Agents Med Chem 8(8);832-6.
PMID:19158510 Yang XH, Zou L (2009) Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination. Cell Cycle 8(2);191-4.
PMID:19202191 Huertas P, Jackson SP (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284(14);9558-65.
PMID:19208614 Chalmers AJ (2009) The potential role and application of PARP inhibitors in cancer treatment. Br. Med. Bull. 89;23-40.
PMID:19217833 Ulrich HD (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst.) 8(4);461-9.
PMID:19225445 Takata K, Wood RD (2009) Bypass specialists operate together. EMBO J. 28(4);313-4.
PMID:19258535 Waters LS, Minesinger BK, Wiltrout ME, D’Souza S, Woodruff RV, Walker GC (2009) Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol. Mol. Biol. Rev. 73(1);134-54.
PMID:19264559 Alpi AF, Patel KJ (2009) Monoubiquitylation in the Fanconi anemia DNA damage response pathway. DNA Repair (Amst.) 8(4);430-5.
PMID:19270065 Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P (2009) MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 37(8);2645-57.
PMID:19270156 Kee Y, Kim JM, D’Andrea AD, D’Andrea A (2009) Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev. 23(5);555-60.
PMID:19282663 Horej-?– Z, Collis SJ, Boulton SJ (2009) FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway. Cell Cycle 8(8);1133-7.
PMID:19342888 Gu B, Chen PL (2009) Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle 8(9);1409-20.
PMID:19357644 Yun MH, Hiom K (2009) CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459(7245);460-3.
PMID:19362533 Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB (2009) Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol. Cell 34(1);13-25.
PMID:19490890 Bernstein KA, Rothstein R (2009) At loose ends: resecting a double-strand break. Cell 137(5);807-10.
PMID:19525936 Peng G, Yim EK, Dai H, Jackson AP, Burgt Iv, Pan MR, Hu R, Li K, Lin SY (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat. Cell Biol. 11(7);865-72.
PMID:19622404 Thompson LH, Hinz JM (2009) Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat. Res. 668(1-2);54-72.
PMID:19654615 Zha S, Boboila C, Alt FW (2009) Mre11: roles in DNA repair beyond homologous recombination. Nat. Struct. Mol. Biol. 16(8);798-800.
PMID:19686080 Moldovan GL, D’Andrea AD (2009) How the fanconi anemia pathway guards the genome. Annu. Rev. Genet. 43;223-49.
PMID:19772495 Hartlerode AJ, Scully R (2009) Mechanisms of double-strand break repair in somatic mammalian cells. Biochem. J. 423(2);157-68.
PMID:19788416 Bitomsky N, Hofmann TG (2009) Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2. FEBS J. 276(21);6074-83.
PMID:19793801 Kaufmann WK (2010) The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis 31(5);751-65.
PMID:19793861 Bansbach CE, B–tous R, Lovejoy CA, Glick GG, Cortez D (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev. 23(20);2405-14.
PMID:19793862 Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ (2009) The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 23(20);2415-25.
PMID:19805513 Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D’Andrea A, Niedernhofer LJ, McHugh PJ (2010) XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol. Cell. Biol. 29(24);6427-37.
PMID:19809470 Cleaver JE, Lam ET, Revet I (2009) Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity. Nat. Rev. Genet. 10(11);756-68.
PMID:19841479 Postow L, Woo EM, Chait BT, Funabiki H (2010) Identification of SMARCAL1 as a component of the DNA damage response. J. Biol. Chem. 284(51);35951-61.
PMID:19847258 Jackson SP, Bartek J (2009) The DNA-damage response in human biology and disease. Nature 461(7267);1071-8.
PMID:19890961 Dupont WD, Breyer JP, Bradley KM, Schuyler PA, Plummer WD, Sanders ME, Page DL, Smith JR (2010) Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. Cancer 116(1);8-19.
PMID:19892829 Taylor EM, Cecillon SM, Bonis A, Chapman JR, Povirk LF, Lindsay HD (2010) The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Res. 38(2);441-54.
PMID:19995904 Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D’Andrea AD (2010) DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol. Cell. Biol. 30(4);1088-96.
PMID:20011137 Saeki T, Ouchi M, Ouchi T (2010) Physiological and oncogenic Aurora-A pathway. Int. J. Biol. Sci. 5(7);758-62.
PMID:20019063 Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK (2010) Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 38(6);1821-31.
PMID:20021983 Ljubojevi-? S, Lipozenci-? J, Celi-? D, Turci-? P (2010) Genital contact allergy. Acta Dermatovenerol Croat 17(4);285-8.
PMID:20029420 Huen MS, Sy SM, Chen J (2010) BRCA1 and its toolbox for the maintenance of genome integrity. Nat. Rev. Mol. Cell Biol. 11(2);138-48.
PMID:20051983 Huertas P (2010) DNA resection in eukaryotes: deciding how to fix the break. Nat. Struct. Mol. Biol. 17(1);11-6.
PMID:20064462 You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T (2010) CtIP links DNA double-strand break sensing to resection. Mol. Cell 36(6);954-69.
PMID:20126263 van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB (2010) A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 8(1);e1000287.
PMID:20376879 Lin SY, Liang Y, Li K (2010) Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei Med. J. 51(3);295-301.
PMID:20457011 Auclair Y, Rouget R, Belisle JM, Costantino S, Drobetsky EA (2010) Requirement for functional DNA polymerase eta in genome-wide repair of UV-induced DNA damage during S phase. DNA Repair (Amst.) 9(7);754-64.
PMID:20478261 Larrea AA, Lujan SA, Kunkel TA (2010) SnapShot: DNA mismatch repair. Cell 141(4);730.e1.
PMID:20603072 Krishnakumar R, Kraus WL (2010) The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol. Cell 39(1);8-24.
PMID:20655466 Ye J, Lenain C, Bauwens S, Rizzo A, Saint-L–ger A, Poulet A, Benarroch D, Magdinier F, Morere J, Amiard S, Verhoeyen E, Britton S, Calsou P, Salles B, Bizard A, Nadal M, Salvati E, Sabatier L, Wu Y, Biroccio A, Londo–o-Vallejo A, Giraud-Panis MJ, Gilson E (2010) TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell 142(2);230-42.
PMID:20723763 Maz–n G, Mimitou EP, Symington LS (2010) SnapShot: Homologous recombination in DNA double-strand break repair. Cell 142(4);646, 646.e1.
PMID:20724832 Huang E, Qu D, Park DS (2011) Cdk5: Links to DNA damage. Cell Cycle 9(16);3142-3.
PMID:21051857 Allington TM, Schiemann WP (2011) The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor— in mammary epithelial cells. Cells Tissues Organs (Print) 193(1-2);98-113.
PMID:21060331 Trainer AH, Lewis CR, Tucker K, Meiser B, Friedlander M, Ward RL (2011) The role of BRCA mutation testing in determining breast cancer therapy. Nat Rev Clin Oncol 7(12);708-17.
PMID:21159657 Sablina AA, Hector M, Colpaert N, Hahn WC (2011) Identification of PP2A complexes and pathways involved in cell transformation. Cancer Res. 70(24);10474-84.
PMID:21199784 Wessler S, Backert S (2011) Abl family of tyrosine kinases and microbial pathogenesis. Int Rev Cell Mol Biol 286;271-300.
PMID:21270334 Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F (2011) Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc. Natl. Acad. Sci. U.S.A. 108(7);2783-8.
PMID:21337561 Euhus DM (2011) New insights into the prevention and treatment of familial breast cancer. J Surg Oncol 103(4);294-8.
PMID:21376459 Li W, Chen Z, Zong Y, Gong F, Zhu Y, Zhu Y, Lv J, Zhang J, Xie L, Sun Y, Miao Y, Tao M, Han X, Xu Z (2011) PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKK– and sustained activation of the NF—B pathway. Cancer Lett. 304(2);117-27.
PMID:21376743 Neal JA, Meek K (2011) Choosing the right path: does DNA-PK help make the decision? Mutat. Res. 711(1-2);73-86.
PMID:21435002 De Braekeleer E, Douet-Guilbert N, Rowe D, Bown N, Morel F, Berthou C, F–rec C, De Braekeleer M (2011) ABL1 fusion genes in hematological malignancies: a review. Eur. J. Haematol. 86(5);361-71.
PMID:21577210 Rodr–guez MI, Gonz–lez-Flores A, Dantzer F, Collard J, de Herreros AG, Oliver FJ (2011) Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. Oncogene 30(42);4365-72.
PMID:21727086 Busso CS, Wedgeworth CM, Izumi T (2011) Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res. 39(18);8017-28.
PMID:21922195 Bolin C, Boudra MT, Fernet M, Vaslin L, Pennaneach V, Zaremba T, Biard D, Cordeli–res FP, Favaudon V, M–gnin-Chanet F, Hall J (2012) The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. Cell. Mol. Life Sci. 69(6);951-62.
PMID:21948210 Su X, Huang J (2012) The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell 2(9);704-11.
PMID:22055391 Chiarugi A (2012) A snapshot of chemoresistance to PARP inhibitors. Trends Pharmacol. Sci. 33(1);42-8.
PMID:22266823 Kim H, Yang K, Dejsuphong D, D’Andrea AD (2012) Regulation of Rev1 by the Fanconi anemia core complex. Nat. Struct. Mol. Biol. 19(2);164-70.
PMID:22615860 Kelsall IR, Langenick J, MacKay C, Patel KJ, Alpi AF (2013) The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair. PLoS ONE 7(5);e36970.
PMID:22713970 Gibson BA, Kraus WL (2012) New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat. Rev. Mol. Cell Biol. 13(7);411-24.
PMID:22751496 Kim H, D’Andrea AD (2012) Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev. 26(13);1393-408.
PMID:22869732 Stecklein SR, Kumaraswamy E, Behbod F, Wang W, Chaguturu V, Harlan-Williams LM, Jensen RA (2012) BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc. Natl. Acad. Sci. U.S.A. 109(34);13650-5.
PMID:22921416 Bai P, Cant– C (2013) The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab. 16(3);290-5.
PMID:22973052 Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson DM, Croteau DL, Bohr VA (2013) Human RECQL5 participates in the removal of endogenous DNA damage. Mol. Biol. Cell 23(21);4273-85.
PMID:23082994 Popp O, Veith S, Fahrer J, Bohr VA, B–rkle A, Mangerich A (2014) Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions. ACS Chem. Biol. 8(1);179-88.
PMID:23444773 Yao CJ, Du W, Zhang Q, Zhang F, Zeng F, Chen FP (2013) Fanconi anemia pathway–the way of DNA interstrand cross-link repair. Pharmazie 68(1);5-11.
PMID:23589330 Cataldo F, Peche LY, Klaric E, Brancolini C, Myers MP, Demarchi F, Schneider C (2013) CAPNS1 regulates USP1 stability and maintenance of genome integrity. Mol. Cell. Biol. 33(12);2485-96.
PMID:196269035 (0) ;.
PMID:224696522 (0) ;.

Leave a Reply