S6K*

Protein S6K* map

Identifiers
ribosomal protein S6 kinase, 70kDa, polypeptide 1
HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 2
HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / MOMP_REGULATION  map

References
synonym:S6K1
synonym:S6K2

S6K*@Cytoplasm

References
a_re376( Apoptosis  map ):
PMID:9465032
PMID:12087098

S6K*|​pho@Cytoplasm

References
a_re631( Apoptosis  map ):
logical:re631_s3146_re638=FALSE
PMID:9381178
in FL5.12 (murine pro-B-cell lymphoid cell, IL-3 dependent) BAD phosphorylated upon IL-3
in 293T, over-expression of wt Akt or myr-Akt, but not kinase mutant induces phosphorylation of BAD
in vitro phosphorylation of BAD by Akt, BAD S112(human S75)A-S136(human S99)A not phosphorylated
PMID:8929531
2D tryptic peptide mapping identifies S112(human S75) and S136(human S99) as the phospho-sites
phsophorylation in FL5.12 in response to IL-3 or PMA
PMID:9346240
in vitro, purified Akt phosphorylates recombinant BAD at S136(human S99) but not at S112(human S75) (serine mutants)
in Balb/c 3T3 upon PDGF or PC12 upon NGF, BAD phosphorylated in an Akt-dependent manner (wortmannin, LY294002)
partial evidence for BAD:Akt interaction
PMID:10230394
mitochondria localized PKA is a BAD-S112(human S75) kinase
PMID:10558990
in vitro purified activated RSK2/RPS6KA3 phosphorylates a peptide encompassing BAD S112(humanS75) phospho-site. Far less efficient as a BAD-S136 kinase
in 293T, over-expression of RSK2 and MEK1 induces phsophorylation of BAD (anti-BAD pS112)
in BDNF-treated cerebellar granule cells, BDNF induces S112 phosphorylation of BAD, in a MEK1-dependent manner (PD098059)
PMID:10837486
RSK is a BAD S112 kinase (anti BAD-phosphoS112)
in vitro,
in HEK293 upon forskolin TPA isoproterenol or insulin-like growth factor, PKA mediated phosphorylation of S155 of murine BAD (human S118)
S118 lies in the BH3 domain of BAD
phosphorylation of S155 independent of that of S112/136
RSK1-2-3 are BAD S155 kinases
PMID:12954615
in vitro, murine PIM2 immunoprecipitated from trasfected U2OS phosphorylates BAD
in U2OS, PIM2 expression but not that of a kinase dead mutant induces BAD S112 phosphorylation
in FDCP1 murine IL3 dependent hematopoietic cells, upon IL3 withdrawal or doxorubicin, PIM2 ectopic expression is protective
PMID:15280015
BAD S112 phosphorylation by PIM1
PMID:17270021
in SW480 human colon carcinoma cell line, correlation between PIM3 expression and BAD phosphorylation. siRNA against PIM3 abrogates BAD S112 and S136 phosphorylation and induces apoptosis
in a set of human colon cancers, correlation and colocalization of PIM3 and BAD phospho-S112
PMID:11493700
S6K purified as a BAD kinase from FL5.12 BCL-XL/BAD cells
in vitro with recombinant proteins, BAD S136 phosphorylation
in FL5.12 by S6K upon IGF, inhibited by rapamycin
in ES p70S6K-/- cells, IGF-induced BAD S136 phosphorylation is lost
PMID:10611223
in FL5.12 upon IL3, PAK1 phosphorylates BAD on S112 and S136, which results in decreased interaction with BCL2 and BCL2L1, and increased interaction with 14-3-3


Modifications:
In compartment: Cytoplasm
  1. S6K*@Cytoplasm map

  2. S6K*|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. S6K*@Cytoplasm map map S6K*|​pho@Cytoplasm map

    As Catalyser:

    1. EIF4B@Cytoplasm map map EIF4B|​S422_pho@Cytoplasm map

    2. PDCD4@Cytoplasm map map PDCD4|​pho@Cytoplasm map
    3. BAD@Cytoplasm map map BAD|​pho@Cytoplasm map

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