S phase

Phenotype S phase map
S phase@default

d_re115( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
Inhibition of Sphase by MRE complex:
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
For role of BLM:TOP3:RMI1 complex in the HR resection step:
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
For inhibition of HR by RECQ5:
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
d_re119( DNA repair  map ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re235( DNA repair  map ):
ATR phosphorylates XPA and activates NER during S-phase in response to damaged DNA, but not during other cc phases:
PMID:16540648, PMID:19004803
d_re236( DNA repair  map ):
Recruitment of all components as POLH and RAD6/RAD18 that ubiguitinate PCNA all together activate TLS:
d_re252( DNA repair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
Link between Fanconi and NER
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
REV1 interacts with many TLS polymerases:
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
FA core complex regulates REV1 and activated TLS
d_re568:( DNA repair  map ) SSB convert to DSB in S phase during DNA replication
d_re577:( DNA repair  map ) Bulky adducts convert to ICL during DNA replication in S phase
d_re587:( DNA repair  map ) reactionType:is.a

In compartment: Cytoplasm
  1. S phase@Cytoplasm map

In compartment: Nucleus

  1. S phase@Nucleus map

In compartment: default

  1. S phase@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. G1 phase@default map map S phase@default map

    2. S phase@default map map G2 phase@default map
    3. Late G1 phase@Cytoplasm map map S phase@Cytoplasm map
    4. S phase@Cytoplasm map map G2 phase@Cytoplasm map
    5. s_s_akt2_s95 map S phase@Nucleus map
    6. S phase@Nucleus map map CKS1B:​CUL1:​SKP1:​SKP2@Nucleus map

    As Catalyser:

    1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

    2. XPA@Nucleus map map XPA|​S196_pho@Nucleus map
    3. RAD18:​RAD6*@default map + POLH@default map + REV1@default map map POLH:​RAD18:​RAD6*:​REV1@default map
    4. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
    5. gDeaminated_alkylated_mismatched_base*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map
    6. gDeaminated_alkylated_mismatched_base*@Nucleus map map gA_NHEJ_DNA_st1*@Nucleus map
    7. gDeaminated_alkylated_mismatched_base*@Nucleus map map gHR_DNA_st1*@Nucleus map
    8. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map
    9. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gA_NHEJ_DNA_st1*@Nucleus map
    10. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gHR_DNA_st1*@Nucleus map
    11. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map
    12. gSingle_strand_breaks_SSB*@Nucleus map map gDouble_strand_breaks_DSB*@Nucleus map
    13. gBbulky_adducts*@Nucleus map map gInterstrand_crosslinks_ICL*@Nucleus map
    14. gInterstrand_crosslinks_ICL*@Nucleus map map gStalled_replication_fork*@Nucleus map
    15. gIntrastrand_crosslinks*@Nucleus map map gStalled_replication_fork*@Nucleus map
    16. gBER_B-glyc_DNA_st2*@Nucleus map map gTLS_DNA_st1*@Nucleus map

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