S phase

Phenotype S phase map
S phase@default

References
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re119( DNA repair  map ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re235( DNA repair  map ):
ATR phosphorylates XPA and activates NER during S-phase in response to damaged DNA, but not during other cc phases:
PMID:16540648, PMID:19004803
d_re236( DNA repair  map ):
Recruitment of all components as POLH and RAD6/RAD18 that ubiguitinate PCNA all together activate TLS:
PMID:16824193
d_re252( DNA repair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011
Link between Fanconi and NER
PMID:22615860
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823
d_re568:( DNA repair  map ) SSB convert to DSB in S phase during DNA replication
d_re577:( DNA repair  map ) Bulky adducts convert to ICL during DNA replication in S phase
d_re587:( DNA repair  map ) reactionType:is.a


Modifications:
In compartment: Cytoplasm
  1. S phase@Cytoplasm map

In compartment: Nucleus

  1. S phase@Nucleus map

In compartment: default

  1. S phase@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. G1 phase@default map map S phase@default map

    2. S phase@default map map G2 phase@default map
    3. Late G1 phase@Cytoplasm map map S phase@Cytoplasm map
    4. S phase@Cytoplasm map map G2 phase@Cytoplasm map
    5. s_s_akt2_s95 map S phase@Nucleus map
    6. S phase@Nucleus map map CKS1B:​CUL1:​SKP1:​SKP2@Nucleus map

    As Catalyser:

    1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

    2. XPA@Nucleus map map XPA|​S196_pho@Nucleus map
    3. RAD18:​RAD6*@default map + POLH@default map + REV1@default map map POLH:​RAD18:​RAD6*:​REV1@default map
    4. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
    5. gDeaminated_alkylated_mismatched_base*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map
    6. gDeaminated_alkylated_mismatched_base*@Nucleus map map gA_NHEJ_DNA_st1*@Nucleus map
    7. gDeaminated_alkylated_mismatched_base*@Nucleus map map gHR_DNA_st1*@Nucleus map
    8. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map
    9. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gA_NHEJ_DNA_st1*@Nucleus map
    10. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gHR_DNA_st1*@Nucleus map
    11. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map
    12. gSingle_strand_breaks_SSB*@Nucleus map map gDouble_strand_breaks_DSB*@Nucleus map
    13. gBbulky_adducts*@Nucleus map map gInterstrand_crosslinks_ICL*@Nucleus map
    14. gInterstrand_crosslinks_ICL*@Nucleus map map gStalled_replication_fork*@Nucleus map
    15. gIntrastrand_crosslinks*@Nucleus map map gStalled_replication_fork*@Nucleus map
    16. gBER_B-glyc_DNA_st2*@Nucleus map map gTLS_DNA_st1*@Nucleus map

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