s_mpk1_re40( Survival ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ζ chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:19615955 PMID:16488589 PMID:15567848
s_mpk1_re41( Survival ):
Among the signalling molecules recruited to phosphorylated LAT is PLCG.
Shp-2 (not modelled) contributes to Ras signalling from the Golgi by stimulating the activation of Src family of kinases and in turn their substrate PLCG.
Participates in complexes:
In compartment: Plasma Membrane
Participates in reactions:
As Reactant or Product:
- RTK*@Plasma Membrane + SRC@Cytoplasm → RTK*:SRC@Plasma Membrane
- RTK*:SRC@Plasma Membrane + PLCG1@Cytoplasm → PLCG1:RTK*:SRC@Plasma Membrane