Complex RTK*:SRC map

Complex composition:

  1. SRC map
  2. RTK* map

RTK*:​SRC@Plasma Membrane


s_mpk1_re40( Survival  map ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ΞΆ chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:19615955 PMID:16488589 PMID:15567848
s_mpk1_re41( Survival  map ):
Among the signalling molecules recruited to phosphorylated LAT is PLCG.
Shp-2 (not modelled) contributes to Ras signalling from the Golgi by stimulating the activation of Src family of kinases and in turn their substrate PLCG.
PMID:16488589 PMID:17496910


Participates in complexes:
In compartment: Plasma Membrane
  1. RTK*:​SRC@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RTK*@Plasma Membrane map + SRC@Cytoplasm map map RTK*:​SRC@Plasma Membrane map

  2. RTK*:​SRC@Plasma Membrane map + PLCG1@Cytoplasm map map PLCG1:​RTK*:​SRC@Plasma Membrane map

As Catalyser:

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