RTK*

Protein RTK* map

Identifiers
Receptor tyrosine kinase
epidermal growth factor receptor
“epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)” ERBB
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)
NGL “v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)”
HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
LCCS2 “lethal congenital contracture syndrome 2″
HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
“v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4″
HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4
fibroblast growth factor receptor 1
FLT2 “fms-related tyrosine kinase 2″ KAL2
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1
fibroblast growth factor receptor 2
“bacteria-expressed kinase” BEK CFD1 “craniofacial dysostosis 1″ “Jackson-Weiss syndrome” JWS “keratinocyte growth factor receptor” KGFR
HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2
fibroblast growth factor receptor 3
ACH “achondroplasia thanatophoric dwarfism”
HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3
fibroblast growth factor receptor 4
HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4
fms-related tyrosine kinase 1
FLT “fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)”
HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1
fms-related tyrosine kinase 3
HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3
fms-related tyrosine kinase 4
HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4
platelet-derived growth factor receptor alpha polypeptide
HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA
platelet-derived growth factor receptor beta polypeptide
HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
insulin-like growth factor 1 receptor
HUGO:IGF1R HGNC:5465 ENTREZ:3480 UNIPROT:P08069 GENECARDS:IGF1R REACTOME:57178 KEGG:3480 ATLASONC:IGF1RID40928ch15q26 WIKI:IGF1R
met proto-oncogene
synonym “hepatocyte growth factor receptor”, HGFR
EPH receptor A1
HUGO:EPHA1 HGNC:3385 ENTREZ:2041 UNIPROT:P21709 GENECARDS:EPHA1 KEGG:2041 ATLASONC:EPHA1ID40461ch7q35 WIKI:EPHA1
EPH receptor A2
EPH receptor B1
EPH receptor B2
PDGFR
A generic name for this family of receptors that contain a tyrosine kinase activity.
rhotekin
HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910
PMID:12040186
PMID:19568798
PMID:14585353
RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase)

RTK*@Plasma Membrane

References
s_mpk1_re25( Survival  map ):
Grb2 is recruited to the plasma membrane by activated RTKs.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
PKC may cause phosphorylation of EGFR leading to a decrease in its activity.
PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473
s_mpk1_re40( Survival  map ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ΞΆ chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
PMID:19615955 PMID:16488589 PMID:15567848
s_mpk1_re272( Survival  map ):
EGF and FGF can induce cell cycle arrest through activation of STAT1 transcription factor.
PMID:15567848
s_mpk1_re273( Survival  map ):
FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR).
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:11447289 PMID:11997436 PMID:15173823
s_mpk1_re284( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
Recruitment of PI 3-kinase by Gab1 results in a positive-feedback loop mediated by binding of the PH domain of Gab1 to the product of PI3-kinase activation phosphatidylinositol-345-triphosphate.
PMID:15567848 PMID:15199124
s_s_mpk1_re40( Survival  map ):
s_s_mpk1_re273( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. RTK*@Cytoplasm map

  2. RTK*|​hm2|​active@Cytoplasm map

In compartment: Plasma Membrane

  1. RTK*@Plasma Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. FGF2:​RTK*@Cytoplasm map

  2. MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  3. MAP3K2_3*|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  4. MAP3K10_11*|​pho:​RAC1|​pho:​RTK*@Cytoplasm map

In compartment: Endosome

  1. GF:​RTK*|​pho|​pho|​hm2@Endosome map

  2. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map

In compartment: Late Endosomes

  1. GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

  2. GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  3. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

In compartment: Lipid Raft

  1. GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map

  2. GF:​RTK*|​pho|​pho|​hm2:​p110*:​p85*@Lipid Raft map
  3. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

In compartment: Plasma Membrane

  1. RTK*:​SRC@Plasma Membrane map

  2. GRB2:​RTK*:​SOS*@Plasma Membrane map
  3. PLCG1:​RTK*:​SRC@Plasma Membrane map
  4. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map
  5. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  6. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  7. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  8. BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  9. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  10. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RTK*@Cytoplasm map map KIT@Cytoplasm map

  2. RTK*@Cytoplasm map map EGFR family*@Cytoplasm map
  3. RTK*@Cytoplasm map map FGFR family*@Cytoplasm map
  4. RTK*@Cytoplasm map + RTK*@Cytoplasm map map RTK*|​hm2|​active@Cytoplasm map
  5. RTK*@Cytoplasm map map IGF1R@Cytoplasm map
  6. RTK*@Cytoplasm map map c-MET*@Cytoplasm map
  7. RTK*@Cytoplasm map map PDGFR family*@Cytoplasm map
  8. RTK*@Cytoplasm map map EPH family*@Cytoplasm map
  9. GF@default map + RTK*@Cytoplasm map map GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map
  10. p110*:​p85*@Cytoplasm map + s_s_akt1_s53 + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
  11. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map map Ubiquitination@Cytoplasm map
  12. GF:​RTK*|​pho|​pho|​hm2@Endosome map map Ubiquitination@Cytoplasm map
  13. GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map map GF:​RTK*|​pho|​pho|​hm2@Endosome map
  14. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  15. GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map + p110*:​p85*@Cytoplasm map map GF:​RTK*|​pho|​pho|​hm2:​p110*:​p85*@Lipid Raft map
  16. RAF1@Cytoplasm map + GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  17. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + RAF1|​pho@Mitochondria map
  18. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + BRAF@Cytoplasm map map BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  19. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K1@Cytoplasm map map MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  20. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K2_3*@Cytoplasm map map MAP3K2_3*|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  21. GRB2:​RTK*:​SOS*@Plasma Membrane map + RAC1@Plasma Membrane map map GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map
  22. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1:​MEK*@Cytoplasm map map BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  23. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map map RAC1@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map
  24. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K10_11*@Cytoplasm map map MAP3K10_11*|​pho:​RAC1|​pho:​RTK*@Cytoplasm map
  25. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*@Cytoplasm map map BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  26. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + LAMTOR2:​MEK*:​MP1*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  27. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  28. RAF1@Cytoplasm map + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  29. ERK*@Cytoplasm map + GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  30. s_s_mpk1_s1009 + RTK*@Plasma Membrane map map GRB2:​RTK*:​SOS*@Plasma Membrane map
  31. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map KSR1:​MEK*@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*|​pho|​pho@Cytoplasm map
  32. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map
  33. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*|​pho|​pho@Cytoplasm map
  34. RTK*@Plasma Membrane map + SRC@Cytoplasm map map RTK*:​SRC@Plasma Membrane map
  35. RTK*:​SRC@Plasma Membrane map + PLCG1@Cytoplasm map map PLCG1:​RTK*:​SRC@Plasma Membrane map
  36. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map RAS*@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map
  37. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  38. RAS*@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  39. FGF2@Extracellular space map + RTK*@Cytoplasm map map FGF2:​RTK*@Cytoplasm map
  40. FGF2:​RTK*@Cytoplasm map map ERK*@Cytoplasm map

As Catalyser:

  1. (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map map (PI3KC1-catalytic*:​PI3KC1-regulator*)|​active@Cytoplasm map

  2. PtdIns(4,5)-P2@Lipid Raft map map PI3,4,5-P3@Lipid Raft map
  3. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map
  4. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map
  5. MAP2K6@Cytoplasm map map MAP2K6|​pho|​pho@Cytoplasm map
  6. MEK*@Cytoplasm map map MEK*|​pho|​pho@Cytoplasm map
  7. STAT1@Nucleus map map STAT1|​unk@Nucleus map
  8. FRS2@Plasma Membrane map map FRS2|​pho@Plasma Membrane map
  9. s_s_mpk1_s1010 map s_s_mpk1_s1008
  10. IMP*:​KSR1:​MEK*@Cytoplasm map map IMP*@Cytoplasm map + KSR1:​MEK*@Cytoplasm map
  11. PIP2@Plasma Membrane map map IP3@Endoplasmic Reticulum map + DAG@Plasma Membrane map
  12. Cytoskeleton:​E-Cadherin*@Cytoplasm map map Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map

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