RSPO3

Protein RSPO3 map

Identifiers
R-spondin 3
“R-spondin 3 homolog (Xenopus laevis)”, “thrombospondin, type I, domain containing 2″, THSD2
HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

RSPO3@Cytoplasm

References
s_wnc1_re111( Survival  map ):
Rspo is required for clathrin-mediated endocytosis
PMID:21397842
It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation.
PMID:16263762
s_wnc1_re113( Survival  map ):
Rspo induces clathrin-mediated endocytosis
s_s_wnc1_re113( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. RSPO3@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

  2. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map

In compartment: Endosome

  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  6. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map

Participates in reactions:
As Reactant or Product:

  1. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. RSPO3@Cytoplasm map map Clathrin-mediated endocytosis@Cytoplasm map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  8. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  9. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map Angiogenesis@Nucleus map
  10. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map + RHOA@Cytoplasm map
  11. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map WNT canonical pathway@Cytoplasm map
  12. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  13. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map

As Catalyser:

  1. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map

  2. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

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