RSK*

Protein RSK* map

Identifiers
ribosomal protein S6 kinase, 90kDa, polypeptide 1
HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 3
HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 2
HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2
“ribosomal protein S6 kinase 90kD polypeptide 1″
“ribosomal protein S6 kinase 90kD polypeptide 2″
CLS “Coffin-Lowry syndrome” “mental retardation X-linked 19″ MRX19 “ribosomal protein S6 kinase 90kD polypeptide 3″
ribosomal protein S6 kinase 90kDa polypeptide 6
“ribosomal protein S6 kinase 90kD polypeptide 6″
HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6
ribosomal protein S6 kinase 90kDa polypeptide 4
HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4
HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 HUGO:LONP1 HGNC:9479 ENTREZ:9361 UNIPROT:P36776 GENECARDS:LONP1 KEGG:9361 ATLASONC:GC_LONP1 WIKI:LONP1
ribosomal protein S6 kinase, 90kDa, polypeptide 5
HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / MOMP_REGULATION  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
synonym:RSK1
synonym:RSK2
synonym:RSK3
RSK2 is a well known ERK substrate in the cytoplasm.
RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments.
PMID:15239952 PMID:15187187
PMID:16286006
PMID:21233202

RSK*@Cytoplasm

References
a_re631( Apoptosis  map ):
logical:re631_s3146_re638=FALSE
PMID:9381178
in FL5.12 (murine pro-B-cell lymphoid cell, IL-3 dependent) BAD phosphorylated upon IL-3
in 293T, over-expression of wt Akt or myr-Akt, but not kinase mutant induces phosphorylation of BAD
in vitro phosphorylation of BAD by Akt, BAD S112(human S75)A-S136(human S99)A not phosphorylated
PMID:8929531
2D tryptic peptide mapping identifies S112(human S75) and S136(human S99) as the phospho-sites
phsophorylation in FL5.12 in response to IL-3 or PMA
PMID:9346240
in vitro, purified Akt phosphorylates recombinant BAD at S136(human S99) but not at S112(human S75) (serine mutants)
in Balb/c 3T3 upon PDGF or PC12 upon NGF, BAD phosphorylated in an Akt-dependent manner (wortmannin, LY294002)
partial evidence for BAD:Akt interaction
PMID:10230394
mitochondria localized PKA is a BAD-S112(human S75) kinase
PMID:10558990
in vitro purified activated RSK2/RPS6KA3 phosphorylates a peptide encompassing BAD S112(humanS75) phospho-site. Far less efficient as a BAD-S136 kinase
in 293T, over-expression of RSK2 and MEK1 induces phsophorylation of BAD (anti-BAD pS112)
in BDNF-treated cerebellar granule cells, BDNF induces S112 phosphorylation of BAD, in a MEK1-dependent manner (PD098059)
PMID:10837486
RSK is a BAD S112 kinase (anti BAD-phosphoS112)
in vitro,
in HEK293 upon forskolin TPA isoproterenol or insulin-like growth factor, PKA mediated phosphorylation of S155 of murine BAD (human S118)
S118 lies in the BH3 domain of BAD
phosphorylation of S155 independent of that of S112/136
RSK1-2-3 are BAD S155 kinases
PMID:12954615
in vitro, murine PIM2 immunoprecipitated from trasfected U2OS phosphorylates BAD
in U2OS, PIM2 expression but not that of a kinase dead mutant induces BAD S112 phosphorylation
in FDCP1 murine IL3 dependent hematopoietic cells, upon IL3 withdrawal or doxorubicin, PIM2 ectopic expression is protective
PMID:15280015
BAD S112 phosphorylation by PIM1
PMID:17270021
in SW480 human colon carcinoma cell line, correlation between PIM3 expression and BAD phosphorylation. siRNA against PIM3 abrogates BAD S112 and S136 phosphorylation and induces apoptosis
in a set of human colon cancers, correlation and colocalization of PIM3 and BAD phospho-S112
PMID:11493700
S6K purified as a BAD kinase from FL5.12 BCL-XL/BAD cells
in vitro with recombinant proteins, BAD S136 phosphorylation
in FL5.12 by S6K upon IGF, inhibited by rapamycin
in ES p70S6K-/- cells, IGF-induced BAD S136 phosphorylation is lost
PMID:10611223
in FL5.12 upon IL3, PAK1 phosphorylates BAD on S112 and S136, which results in decreased interaction with BCL2 and BCL2L1, and increased interaction with 14-3-3

RSK*|​pho@Nucleus

References
s_mpk1_re97( Survival  map ):
RSK2 is a well known ERK substrate in the cytoplasm.
Activated RSK can be found in both nuclear and cytoplasmic compartments.
PMID:15239952 PMID:15187187
s_mpk1_re177( Survival  map ):
Phosphorylation by both ERKs and their downstream RSKs can stabilise the c-FOS protein for several hours. The combination of these phosphorylations allows c-FOS sustained activity.
PMID:16393692

RSK*|​pho@Cytoplasm

References
s_mpk1_re94( Survival  map ):
RSK2 is a well known ERK substrate in the cytoplasm and has been shown to undergo autophosphorylation after ERK phosphorylation.
RSKs interact with ERK and dissociate upon activation.
Results suggested that KSR1 was the scaffold utilised by ERK1/2 for activating cPLA2 but not RSK1.
PMID:15239952 PMID:15187187 PMID:19114553
s_mpk1_re97( Survival  map ):
RSK2 is a well known ERK substrate in the cytoplasm.
Activated RSK can be found in both nuclear and cytoplasmic compartments.
PMID:15239952 PMID:15187187
s_mpk1_re109( Survival  map ):
ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex.
PMID:16039586

RSK*@Nucleus

References
s_wnc3_re11:( Survival  map ) PMID:15657420


Modifications:
In compartment: Cytoplasm
  1. RSK*@Cytoplasm map

  2. RSK*|​pho@Cytoplasm map

In compartment: Nucleus

  1. RSK*@Nucleus map

  2. RSK*|​pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. ERK*|​pho|​pho:​GSK3_beta_*|​pho:​RSK*|​pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. ERK*|​pho|​pho@Cytoplasm map + GSK3_beta_*@Cytoplasm map + RSK*|​pho@Cytoplasm map map ERK*|​pho|​pho:​GSK3_beta_*|​pho:​RSK*|​pho@Cytoplasm map

  2. RSK*@Cytoplasm map map RSK*|​pho@Cytoplasm map
  3. RSK*|​pho@Cytoplasm map map RSK*|​pho@Nucleus map
  4. MAPK pathway@Cytoplasm map map RSK*@Nucleus map

As Catalyser:

  1. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map

  2. DAPK1@Cytoplasm map map DAPK1|​S289_pho@Cytoplasm map
  3. EIF4B@Cytoplasm map map EIF4B|​S422_pho@Cytoplasm map
  4. BimEL*|​S69_pho@Cytoplasm map map BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map
  5. BAD@Cytoplasm map map BAD|​pho@Cytoplasm map
  6. EIF4B@Cytoplasm map map EIF4B|​S422_pho@Cytoplasm map
  7. FOS@Nucleus map map FOS|​pho@Nucleus map
  8. NFAT3*@Nucleus map map NFAT3*|​S676_pho@Nucleus map

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