RPA1:RPA2:RPA3

Complex RPA1:RPA2:RPA3 map


Complex composition:

  1. RPA2 map
  2. RPA1 map
  3. RPA3 map




RPA1:​RPA2|​pho:​RPA3@default

Identifiers
NAME:RPA1:RPA2:RPA3

Maps_Modules
 DNA repair  map  / NER  map
 DNA repair  map  / MMR  map

References
d_re45:( DNA repair  map ) PMID:16731533

Confidence
REF=1 FUNC=5

RPA1:​RPA2:​RPA3@default

Identifiers
NAME:RPA1:RPA2:RPA3

Maps_Modules
 DNA repair  map  / NER  map
 DNA repair  map  / MMR  map

References
d_re136( DNA repair  map ):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
d_re156( DNA repair  map ):
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
PMID:19622404
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862
d_re355( DNA repair  map ):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. RPA1:​RPA2:​RPA3@default map

  2. RPA1:​RPA2|​pho:​RPA3@default map

Participates in reactions:
As Reactant or Product:

  1. d_s2743 + d_s834 + EXO1@default map + RPA1:​RPA2:​RPA3@default map + PCNA@default map + RFC*@Nucleus map map EXO1:​PCNA:​RFC*:​RPA1:​RPA2:​RPA3:​hMutL*:​hMutS*@Nucleus map

  2. RPA1:​RPA2:​RPA3@default map + SMARCAL1|​pho@default map map RPA1:​RPA2:​RPA3:​SMARCAL1|​pho@default map
  3. CDK7:​CyclinH*:​MNAT1:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XPB*:​XPD*@default map + RPA1:​RPA2|​pho:​RPA3@default map + XAB2:​XPA|​S196_pho@default map map CDK7:​CyclinH*:​MNAT1:​RPA1:​RPA2|​pho:​RPA3:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*@default map
  4. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  5. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map
  6. POLE*@default map + POLD*@default map + RFC*@Nucleus map + PCNA@default map + CHTF18@default map + POLK@default map + XRCC1|​pho@default map + RPA1:​RPA2|​pho:​RPA3@default map map CHTF18:​PCNA:​POLD*:​POLE*:​POLK:​RFC*:​RPA1:​RPA2|​pho:​RPA3:​XRCC1|​pho@default map
  7. RAD52@default map + RPA1:​RPA2|​pho:​RPA3@default map map RAD52:​RPA1:​RPA2|​pho:​RPA3@default map
  8. RPA1@default map + RPA2|​pho@default map + RPA3@default map map RPA1:​RPA2|​pho:​RPA3@default map
  9. POLD*@default map + RPA1:​RPA2|​pho:​RPA3@default map map POLD*:​RPA1:​RPA2|​pho:​RPA3@default map
  10. ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RPA1:​RPA2:​RPA3@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  11. RPA1@default map + RPA2@default map + RPA3@default map map RPA1:​RPA2:​RPA3@default map

As Catalyser:

  1. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map

  2. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  3. TOPBP1@default map + ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RAD17|​pho@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map
  4. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map

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