ROS

Simple molecule ROS map
ROS@Nucleus

Identifiers
CHEBI:26523

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:16001073
RAC1B increases the cellular level of ROS, causing an upregulation of Snail and induction of EMT
e_re8( EMT  map ):
RAC1B increases the cellular level of ROS, causing an upregulation of Snail rexpression and induction of EMT

ROS@Mitochondria

Identifiers
CHEBI:26523

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:16001073
RAC1B increases the cellular level of ROS, causing an upregulation of Snail and induction of EMT
e_re1257( EMT  map ):
PMID:10833514
Hypoxia increases mitochondrial ROS generation at Complex III, which causes accumulation of HIF-1alpha protein
Mitochondria-derived ROS are both required and sufficient to initiate HIF-1 alpha stabilization during hypoxia.

ROS@Mitochondrial Matrix

Identifiers
CHEBI:26523

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / TNF_RESPONSE  map

References
a_re81:( Apoptosis  map ) reactionType:is.a

ROS@Cytoplasm

Identifiers
CHEBI:26523

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / TNF_RESPONSE  map

References
a_re875( Apoptosis  map ):
PMID:12456881
in Hela, knocking down BLVRA knock down induces oxidative stress
in vitro, with recombinant catalytic BLVRA

ROS@Mitochondrial inner membrane

References
a_re730( Apoptosis  map ):
PMID:20043986
in isolated mitochondria, Ca2+-dependent and ROS-mediated carbonylation of AIF.
carbonylated AIF as a prefered substrate for calpains


Modifications:
In compartment: Cytoplasm
  1. ROS@Cytoplasm map

In compartment: Mitochondria

  1. ROS@Mitochondria map

In compartment: Mitochondrial Matrix

  1. ROS@Mitochondrial Matrix map

In compartment: Mitochondrial inner membrane

  1. ROS@Mitochondrial inner membrane map

In compartment: Nucleus

  1. ROS@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Fe2+:​PHD*@Cytoplasm map + ROS@Cytoplasm map map Fe3+:​PHD*@Cytoplasm map

    2. AIFM1@Mitochondrial inner membrane map + ROS@Mitochondrial inner membrane map map AIFM1|​don@Mitochondrial inner membrane map
    3. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map map ROS@Mitochondrial Matrix map
    4. H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map map ROS@Mitochondrial Matrix map
    5. hydroxyl@Cytoplasm map map ROS@Cytoplasm map
    6. H_sub_2_endsub_O_sub_2_endsub_@Cytoplasm map map ROS@Cytoplasm map
    7. O_sub_2_endsub__super_-_endsuper_@Cytoplasm map map ROS@Cytoplasm map
    8. bilirubin@Cytoplasm map + ROS@Cytoplasm map map biliverdin@Cytoplasm map
    9. Mitochondria dysfunction@Nucleus map map ROS@Nucleus map
    10. Phagocytes@Nucleus map map ROS@Nucleus map
    11. Toxic compounds@Nucleus map map ROS@Nucleus map
    12. ROS@Nucleus map map Lipid peroxides*@Nucleus map
    13. RAC1B*@Nucleus map map ROS@Nucleus map
    14. Hypoxia@Cytoplasm map map ROS@Mitochondria map
    15. ROS@Mitochondria map map ROS@Nucleus map
    16. ROS@Mitochondria map map HIF1A@Cytoplasm map
    17. TNFRSF1B:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map
    18. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map

    As Catalyser:

    1. gMT-DNA*@Mitochondrial Matrix map map Mitochondrial~DNA damage@Mitochondrial Matrix map

    2. NFE2L2@Cytoplasm map map NFE2L2|​ubi@Cytoplasm map
    3. ACO2@Mitochondrial Matrix map map ACO2|​oxidized@Mitochondrial Matrix map
    4. gIntact_DNA*@Nucleus map map gDeaminated_alkylated_mismatched_base*@Nucleus map
    5. gIntact_DNA*@Nucleus map map gGG-NER_DNA_st1*@Nucleus map
    6. gIntact_DNA*@Nucleus map map gDR_DNA_st1*@Nucleus map
    7. gIntact_DNA*@Nucleus map map gOxidized_ring-saturated_hydrolysed_base*@Nucleus map
    8. rSNAI1@Nucleus map map SNAI1@Nucleus map
    9. s_s_mpk1_s1037 map MAP3K5@Cytoplasm map + TXN@Cytoplasm map
    10. DUSP1@Nucleus map map DUSP1|​don@Nucleus map
    11. DUSP5@Nucleus map map DUSP5|​don@Nucleus map

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