RIPK1:TNFRSF1A:TRADD:TRAF2

Complex RIPK1:TNFRSF1A:TRADD:TRAF2 map


Complex composition:

  1. TRADD map
  2. TRAF2 map
  3. RIPK1 map
  4. TNFRSF1A map




RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane

Identifiers
NAME:RIPK1:TNFRSF1A:TRADD:TRAF2

References
s_mpk1_re123( Survival  map ):
TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane.
PMID:11274345
s_mpk1_re132( Survival  map ):
Endogenous TAK1 is activated by TGF-beta IL-1 and TNF.
s_mpk1_re138( Survival  map ):
MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner.
s_mpk1_re141:( Survival  map ) Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation
s_mpk1_re147( Survival  map ):
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12655147
s_s_mpk1_re132( Survival  map ):
s_s_mpk1_re138( Survival  map ):

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

  2. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  3. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  4. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1049
  5. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048

As Catalyser:

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