RIPK1

Protein RIPK1 map

Identifiers
receptor (TNFRSF)-interacting serine-threonine kinase 1
HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 GENECARDS:RIPK1 REACTOME:63119 KEGG:8737 ATLASONC:GC_RIPK1 WIKI:RIPK1

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane.
PMID:11274345

RIPK1|​ubi@TNFRSF1 Receptor Complex

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / TNF_RESPONSE  map

References
K48-linked ubiquitin chains
a_re1333:( Apoptosis  map ) PMID:19131965

RIPK1|​K377_ubi@TNFRSF1 Receptor Complex

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / TNF_RESPONSE  map

References
K63-linked ubiquitin chain
a_re1210( Apoptosis  map ):
PMID:18570872
PMID:18621737
a_re1215:( Apoptosis  map ) PMID:16603398
a_re1331( Apoptosis  map ):
PMID:19131965
role of RNF11 in the A20 complex

RIPK1|​S161_pho@TNFRSF1 Receptor Complex

References
a_re1280( Apoptosis  map ):
PMID:17389591
in aortic endothelial cells

RIPK1@Cytoplasm

References
a_re1149( Apoptosis  map ):
PMID:12441346
in murine L929 cell line, RIPK1 is a HSP90 client protein

RIPK1@TNFRSF1 Receptor Complex

References
a_re1331( Apoptosis  map ):
PMID:19131965
role of RNF11 in the A20 complex
a_re1210( Apoptosis  map ):
PMID:18570872
PMID:18621737
a_re1234( Apoptosis  map ):
PMID:20125124
by HTRA2
PMID:10521396
by CASP8
PMID:19935698
by CASP2

RIPK1|​unfolded@Cytoplasm

References
a_re1149( Apoptosis  map ):
PMID:12441346
in murine L929 cell line, RIPK1 is a HSP90 client protein


Modifications:
In compartment: Cytoplasm
  1. RIPK1@Cytoplasm map

  2. RIPK1|​unfolded@Cytoplasm map

In compartment: TNFRSF1 Receptor Complex

  1. RIPK1@TNFRSF1 Receptor Complex map

  2. RIPK1|​ubi@TNFRSF1 Receptor Complex map
  3. RIPK1|​K377_ubi@TNFRSF1 Receptor Complex map
  4. RIPK1|​S161_pho@TNFRSF1 Receptor Complex map

Participates in complexes:
In compartment: Cytoplasm

  1. FADD:​RIPK1:​TRADD@Cytoplasm map

  2. CFLAR:​FADD:​RIPK1:​TRADD@Cytoplasm map

In compartment: Plasma Membrane

  1. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RIPK1|​unfolded@Cytoplasm map map RIPK1@Cytoplasm map

  2. FADD:​RIPK1:​TRADD@Cytoplasm map + CFLAR@Cytoplasm map map CFLAR:​FADD:​RIPK1:​TRADD@Cytoplasm map
  3. RIPK1@Cytoplasm map map RIPK1|​unfolded@Cytoplasm map
  4. RIPK1@Cytoplasm map map RIPK1@TNFRSF1 Receptor Complex map
  5. RIPK1@TNFRSF1 Receptor Complex map map RIPK1|​K377_ubi@TNFRSF1 Receptor Complex map
  6. RIPK1@TNFRSF1 Receptor Complex map map cleaved~RIPK1*@TNFRSF1 Receptor Complex map
  7. RIPK1|​K377_ubi@TNFRSF1 Receptor Complex map map RIPK1@TNFRSF1 Receptor Complex map
  8. RIPK1|​ubi@TNFRSF1 Receptor Complex map map degraded
  9. RIPK1@TNFRSF1 Receptor Complex map map RIPK1|​ubi@TNFRSF1 Receptor Complex map
  10. TRADD@TNFRSF1 Receptor Complex map + RIPK1@TNFRSF1 Receptor Complex map + FADD@Cytoplasm map map FADD:​RIPK1:​TRADD@Cytoplasm map
  11. RIPK3@TNFRSF1 Receptor Complex map + RIPK1@TNFRSF1 Receptor Complex map map RIPK3|​S199_pho@TNFRSF1 Receptor Complex map + RIPK1|​S161_pho@TNFRSF1 Receptor Complex map
  12. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  13. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  14. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  15. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1049
  16. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048

As Catalyser:

  1. TAB*@Cytoplasm map map TAB*@TNFRSF1 Receptor Complex map

  2. IKBKG@Cytoplasm map map IKBKG@TNFRSF1 Receptor Complex map
  3. DAB2IP@TNFRSF1 Receptor Complex map map DAB2IP|​S604_pho@TNFRSF1 Receptor Complex map
  4. RIPK3@Cytoplasm map map RIPK3@TNFRSF1 Receptor Complex map
  5. Caspase8*@Cytoplasm map map cleaved~Caspase8*@Cytoplasm map

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