RhoB_GEFs*

Protein RhoB_GEFs* map

Identifiers
RhoB_GEFs*
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2 HGNC:682 ENTREZ:9181 UNIPROT:Q92974 GENECARDS:ARHGEF2 REACTOME:195090 KEGG:9181 ATLASONC:ARHGEF2ID43150ch1q22 WIKI:ARHGEF2
Rho guanine nucleotide exchange factor (GEF) 3
HUGO:ARHGEF3 HGNC:683 ENTREZ:50650 UNIPROT:Q9NR81 GENECARDS:ARHGEF3 REACTOME:414718 KEGG:50650 ATLASONC:GC_ARHGEF3 WIKI:ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L HGNC:25540 ENTREZ:55160 UNIPROT:Q9HCE6 GENECARDS:ARHGEF10L KEGG:55160 ATLASONC:GC_ARHGEF10L WIKI:ARHGEF10L

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

RhoB_GEFs*@Cytoplasm

References
e_re727( EMT  map ):
PMID:9857026
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
PMID:16917499
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.
PMID:12221096
XPLN (so-called ARHGEF3) is a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
PMID:9822605
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein


Modifications:
In compartment: Cytoplasm
  1. RhoB_GEFs*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoB_GEFs*@Cytoplasm map map ARHGEF2@Cytoplasm map

    2. RhoB_GEFs*@Cytoplasm map map ARHGEF3@Cytoplasm map
    3. RhoB_GEFs*@Cytoplasm map map ARHGEF10L@Cytoplasm map
    4. RhoB_GEFs*@Cytoplasm map map VAV2@Cytoplasm map

    As Catalyser:

    1. GDP:​RHOB@Cytoplasm map map GTP:​RHOB@Cytoplasm map

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