Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2 HGNC:682 ENTREZ:9181 UNIPROT:Q92974 GENECARDS:ARHGEF2 REACTOME:195090 KEGG:9181 ATLASONC:ARHGEF2ID43150ch1q22 WIKI:ARHGEF2
Rho guanine nucleotide exchange factor (GEF) 3
HUGO:ARHGEF3 HGNC:683 ENTREZ:50650 UNIPROT:Q9NR81 GENECARDS:ARHGEF3 REACTOME:414718 KEGG:50650 ATLASONC:GC_ARHGEF3 WIKI:ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L HGNC:25540 ENTREZ:55160 UNIPROT:Q9HCE6 GENECARDS:ARHGEF10L KEGG:55160 ATLASONC:GC_ARHGEF10L WIKI:ARHGEF10L
e_re727( EMT ):
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.
XPLN (so-called ARHGEF3) is a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- RhoB_GEFs*@Cytoplasm → ARHGEF2@Cytoplasm
- RhoB_GEFs*@Cytoplasm → ARHGEF3@Cytoplasm
- RhoB_GEFs*@Cytoplasm → ARHGEF10L@Cytoplasm
- RhoB_GEFs*@Cytoplasm → VAV2@Cytoplasm